Research Interests

Our research uses a wide range of approaches to investigate the sources, fate, and hazards of genotoxic substances.

Research

Prof. White's current research is primarily focussed on the development, validation and deployment of in vitro systems for the detection of genetic toxicity. The work involves the creation and validation of in vitro tools derived from the transgenic MutaMouse; moreover, the development of high(er) throughput in vitro testing platforms to effectively and efficiently detect and quantify genetic toxicity. In addition, his current work involves the development and application of dose-response analysis approaches to determine point-of-departure metrics for human health risk assessment.

Current research projects:

1. GeneTox21 - An Integrated Platform for In vitro Genetic Toxicity Assessment and Regulatory Evaluation of New and Existing Substances.
2. Refining and Deploying a Quantitative Framework for the Analysis and Regulatory Interpretation of Genetic Toxicity Dose-Response Data.
3. The In Vivo Mutagenic Activity of Urban Air Particulate Matter.
4. The Development and Deployment of an Air-liquid Interface Exposure System for In Vitro Toxicity Assessment of Complex Aerosols.