Keir, JLA, Akhta, US, Matschke, DMJ, Kirkham, TL, Chan, HM, Ayotte, P, White, PA and JM Blais. 2017. Elevated exposures to polycyclic aromatic hydrocarbons and other organic mutagens in Ottawa firefighters participating in emergency, on-shift fire suppression. Environmental Science and Technology, in press.

Wills, JW, Summers, HD, Hondow, N, Sooresh, A, Meissner, KE, White, PA, Rees, P, Brown, AP and SH Doak. 2017. Tipping points in nanoparticle agglomeration and cellular dosimetry. ACS Nano, in press.

Wills, JW, Johnson, GE, Battaion, HL, Slob, W. and PA White. 2017. Comparing BMD-derived genotoxic potency estimations across variants of the transgenic rodent gene mutation assay. Environmental and Molecular Mutagenesis, in press.

Maertens, RM, Long, AS and PA White. 2017. Performance of the in vitro transgene mutation assay in MutaMouse FE1 cells: Evaluation of nine misleading ("False") positive chemicals. Environmental and Molecular Mutagenesis, 58(8): 582-591. doi: 10.1002/em.22125. Reprint available at http://onlinelibrary.wiley.com/doi/10.1002/em.22125/full.

White, PA, Douglas, GR, Phillips, DH and VM Arlt. 2017. Quantitative Relationships Between lacZ Mutant Frequency and DNA Adduct Frequency in Muta™Mouse Tissues and Cultured Cells Exposed to 3-Nitrobenzanthrone. Mutagenesis 32:299-312. Reprint available at https://academic.oup.com/mutage/article/doi/10.1093/mutage/gew067/2911526/Quantitative-relationships-between-lacZ-mutant.

Long, AS, Lemieux, CL, Gagné, R, Lambert, IB and PA White. 2017. The Genetic Toxicity of Complex Mixtures of Polycyclic Aromatic Hydrocarbons: Evaluating Dose-Additivity in a Transgenic Mouse Model. Environmental Science and Technology, 51:8138-8148. Reprint available at http://pubs.acs.org/doi/abs/10.1021/acs.est.7b00985.

Zavala, J, Greenan, RD, Chorley, BN, Hanley, NM, Krantz, QT, King, C, DeMarini, DM, Higuchi, M, Gilmour, MI and PA White. 2017. Regulating temperature and relative humidity in air–liquid interface in vitro systems eliminates cytotoxicity resulting from control air exposures. Toxicology Research, 6:448-459. Reprint available at http://pubs.rsc.org/en/content/articlelanding/2017/tx/c7tx00109f/unauth#!divAbstract.

Avancini, D, Menzies, G, Morgan, C, Wills, J, Johnson, GE, White, PA and PD Lewis. 2016. MutAIT – online genetic toxicology data portal and analysis tools. Mutagenesis 31:-323-328. Reprint available at https://academic.oup.com/mutage/article/31/3/323/2622788/MutAIT-an-online-genetic-toxicology-data-portal.

Wills, JW, Johnson, GE, Doak, SH, Soeteman-Hernández, LG, and PA White. 2016. Empirical Analysis of BMD metrics in genetic toxicology part I: in vitro analyses to provide robust potency rankings and support MOA determinations. Mutagenesis 31:255-263. Reprint available at https://academic.oup.com/mutage/article/31/3/255/2622802/Empirical-analysis-of-BMD-metrics-in-genetic.

Wills, JW, Long, AS, Johnson, GE, Bemis, JC, Dertinger, SD, Slob, W and PA White. 2016. Empirical analysis of BMD metrics in genetic toxicology part II: in vivo potency comparisons to promote reductions in the use of experimental animals for genetic toxicity assessment. Mutagenesis 31:265-275. Reprint available at https://academic.oup.com/mutage/article/31/3/265/2622803.

Long, AS, Lemieux, CL and PA White. 2016. Tissue-specific in vivo genetic toxicity of nine polycyclic aromatic hydrocarbons assessed using the Muta™Mouse transgenic rodent assay. Toxicology and Applied Pharmacology 290:31-42. Reprint available at http://www.sciencedirect.com/science/article/pii/S0041008X1530137X.

Cox, JA, Fellows, M., Hashizume, T. and PA White. 2016. The utility of metabolic activation mixtures containing human hepatic post-mitochondrial supernatant (S9) for in vitro genetic toxicity assessment. Mutagenesis 31:117-130. Reprint available at https://academic.oup.com/mutage/article/31/2/117/2622798/The-utility-of-metabolic-activation-mixtures.

White, PA and GE Johnson. 2016. Genetic toxicology at the crossroads – from qualitative hazard evaluation to quantitative risk assessment. Mutagenesis 31: 233-237. Reprint available at https://academic.oup.com/mutage/article/31/3/233/2622804.

Chepelev, NL, Long, AS, Williams, A, Kuo, B, Gagné, R., Kennedy, DA, Arlt, VM, White, PA and CL Yauk. 2016. Transcriptional profiling of dibenzo[def,p]chrysene-induced spleen atrophy provides mechanistic insights into its immunotoxicity in MutaTMMouse. Toxicological Sciences, 149:251-268. Reprint available at https://academic.oup.com/toxsci/article/149/1/251/2461775.

Luijten, M, Zwart, EP, Dollé, MET, de Pooter, M, Cox, JA, White, PA and J van Benthem. 2016. Evaluation of the LacZ reporter assay in cryopreserved primary hepatocytes for in vitro genotoxicity testing. Environmental and Molecular Mutagenesis. 57:643-655. Reprint available at http://onlinelibrary.wiley.com/doi/10.1002/em.22063/full.

Chepelev, NL, Long, AS, Bowers, WJ, Gagne, R, Williams, A, Kuo, B, Phillips, DH, Arlt, VM, White, PA and CL Yauk. 2016. Transcriptional profiling of the mouse hippocampus supports an NMDAR-mediated neurotoxic mode of action for benzo[a]pyrene. Environmental and Molecular Mutagenesis. 57:350-363. Reprint available at http://onlinelibrary.wiley.com/doi/10.1002/em.22020/full.

Long, AS, Watson, M, Arlt, VM and PA White. 2016. Oral Exposure to Commercially Available Coal Tar-Based Pavement Sealcoat Induces Murine Genetic Damage and Mutations. Environmental and Molecular Mutagenesis, 7:335-545. Reprint available at http://onlinelibrary.wiley.com/doi/10.1002/em.22032/full.

Valente WJ, Ericson NG, Long AS, White PA, Marchetti F, Bielas JH. 2016. Mitochondrial DNA exhibits resistance to induced point and deletion mutations. Nucleic Acids Research. 44:8513-8524. Reprint available at https://academic.oup.com/nar/article/44/18/8513/2468358.

Wills, JW, Hondow, N, Thomas, AD, Chapman, KE, Fish, D, Maffeis, TG, Penny, MW, Brown, RA, Jenkins, GJS, Brown, AP, White, PA and SH Doak. 2016. Genetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm™). Particle and Fiber Toxicology 13:50. DOI: 10.1186/s12989-016-0161-5. Reprint available at https://particleandfibretoxicology.biomedcentral.com/articles/10.1186/s12989-016-0161-5?elqTrackId=964d0145843a4f05ba73fad62bab9743&elq= 73d851f145fa424a872c13a0ce22aa98&elqaid=16736&elqat=1&elqCampaignId=9215.

Irvine, G., Blais, JM, Doyle, JR, Kimpe, LE and PA White. 2014. Cancer risk to First Nations’ people from exposure to polycyclic aromatic hydrocarbons near in-situ bitumen extraction in Cold Lake, Alberta. BMC Environmental Health, 13(1):Article 7. Reprint available at https://ehjournal.biomedcentral.com/articles/10.1186/1476-069X-13-7.

Johnson, GE, Rees, B, Gollapudi, BB, Heflich, B, Doak, S, Soeteman-Hernandez, L, Fellows, M, Slob, W, Verma, J, Wills, J, Jenkins, G and PA White. 2015. New approaches to advance the use of genetic toxicology analyses for human health risk assessment. Toxicology Research 4:667-676. Reprint available at http://pubs.rsc.org/-/content/articlelanding/2015/tx/c4tx00118d/unauth#!divAbstract.

Zeiger, E., Gollapudi, BB, Aardema, MJ, Auerbach, S, Boverhof, D, Custer, L, Dedon, P, Honma, M, Ishida, S, Kasinski, AL, Kim, JH, Manjanatha, MG, Marlowe, J, Pfuhler, S, Pogribny, I, Slikker, W, Stankowski, Jr., LF, Tanir, JY, Tice, R, van Benthem, J, White, PA, Witt, KL and V Thybaud. 2015. Opportunities to integrate new approaches in genetic toxicology: an ILSI-HESI workshop report. Environmental & Molecular Mutagenesis 56:277-285. Reprint available at http://onlinelibrary.wiley.com/doi/10.1002/em.21923/full.

Gollapudi, BB, Lynch, AM, Heflich, RH, Dertinger, SD, Dobrovolsky, VN, Froetschl, R, Horibata, K, Kenyon, MO, Kimoto, T, Lovell, DP, Stankowski Jr., LF, White, PA, Witt, KL, and JY Tanir. 2015. The In Vivo Pig-a assay: a report of the International Workshop on Genotoxicity Testing (IWGT) workgroup. Mutation Research 783:23-35. Reprint available at http://www.sciencedirect.com/science/article/pii/S1383571814002472.

MacGregor, JT, Frötschl, R, White, PA, Crump, KS, Eastmond, DA, Fukushima, S, Guérard, M, Hayashi, M, Soeteman-Hernandez, L, Kasamatsu, T, Levy, DD, Morita, T, Müller, L, Schoeny, R, Schuler, MJ, Thybaud, V, and GE Johnson. 2015. IWGT Report on quantitative approaches to genotoxicity risk assessment I. Methods and metrics for defining exposure-response relationships and points of departure (PoDs). Mutation Research 783:55-65. Reprint available at http://www.sciencedirect.com/science/article/pii/S1383571814002605.

MacGregor, JT, Frötschl, R, White, PA, Crump, KS, Eastmond, DA, Fukushima, S, Guérard, M, Hayashi, M, Soeteman-Hernandez, L, Johnson, GE, Kasamatsu, T, Levy, DD, Morita, T, Müller, L, Schoeny, R, Schuler, MJ and V Thybaud. 2015. IWGT report on quantitative approaches to genotoxicity risk assessment II. Use of Point-of-Departure (PoD) metrics in defining acceptable exposure limits and assessing human risk. Mutation Research 783:66-78. Reprint available at http://www.sciencedirect.com/science/article/pii/S1383571814002861.

Lemieux, CL, Long, AS, Lambert, IB, Lundstedt, S, Tysklind, M and PA White. 2015. In Vitro mammalian mutagenicity of complex polycyclic aromatic hydrocarbon mixtures in contaminated soils. Environmental Science and Technology. 49:1787-1796. Reprint available at http://www.diva-portal.org/smash/record.jsf?pid=diva2%3A791612&dswid=6548.

Lemieux, CL, Long, AS, Lambert, IB, Lundstedt, S, Tysklind, M and PA White. 2015. Cancer risk assessment of polycyclic aromatic hydrocarbon contaminated soils determined using bioassay-derived levels of benzo[a]pyrene equivalents. Environmental Science and Technology. 49:1797-1805. Reprint available at http://www.diva-portal.org/smash/record.jsf?pid=diva2%3A791615&dswid=-2039.

Kucab, JE, van Steeg H, Luitjen, M, Schmeiser, HH, White, PA, Phillips, DH and VM Arlt. 2015. TP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts. Mutation Research 773:48-62. Reprint available at http://www.sciencedirect.com/science/article/pii/S002751071500024X.

Chepelev, NL, Kennedy, DA, Gagné, R., White, T., Long, AS, Yauk, CL, and PA White. 2015. HPLC measurement of the DNA oxidation biomarker, 8-oxo-7,8-dihydro-2’-deoxyguanosine, in cultured cells and animal tissues. Journal of Visualised Experiments, 102:e52697, doi:10.3791/52697. Reprint available at https://www.jove.com/video/52697/hplc-measurement-dna-oxidation-biomarker-8-oxo-78-dihydro-2.

Labib S, Williams A, Guo CH, Leingartner K, Arlt VM, Schmeiser HH, Yauk CL, White, PA and S Halappanavar. 2015. Comparative transcriptomic analyses to scrutinize the assumption that genotoxic PAHs exert effects via a common mode of action. Archives of Toxicology 90:2461-2480. Reprint available at https://link.springer.com/article/10.1007/s00204-015-1595-5.

Johnson, GE, Soeteman-Hernández, LG, Gollapudi, BB, Bodger, OG, Dearfield, KL, Heflich, RH, Hixon, JG, Lovell, P., MacGregor, JT, Pottenger, LH, Thompson, CM, Abraham, L, Thybaud, V, Young Tanir, J, Zeiger, E, van Benthem, J and PA White. 2014. Derivation of points of departure (PoD) estimates in genetic toxicology studies and their potential application in risk assessment. Environmental & Molecular Mutagenesis 55:609-623. Reprint available at http://onlinelibrary.wiley.com/doi/10.1002/em.21870/full.

Long, AL, Lemieux, C, Yousefi, P, Ruiz-Mercado, I, Lam, N, Orellana, C, White, PA, Holland, N, and K Smith. 2014. Human urinary mutagenicity after woodsmoke exposure during traditional temazcal use. Mutagenesis 29:367-377. Reprint available at https://academic.oup.com/mutage/article/29/5/367/2763469.

Maertens, RM and PA White. 2014. Letter to the Editor regarding Seager et al. 2014 Mutagenesis 29:155-164 (Recommendations, evaluation and validation of a semi-automated, fluorescent-based scoring protocol for micronucleus testing in human cells" describes the use of the MetaSystems microscope for more efficient scoring of micronuclei). Mutagenesis 30:311-12. Reprint available at https://academic.oup.com/mutage/article/30/2/311/1357150.