Publications

Jahan, S.; Adam, M. K.; Manesia, J. K.; Doxtator, E.; Ben, R. N.; Pineault, N. Inhibition of Ice Recrystallization during Cryopreservation of Cord Blood Grafts Improves Platelet Engraftment. Transfusion 2020, 9999, 1–10.

Diaz-Dussan, D.; Peng, Y.-Y.; Sengupta, J.; Zabludowski, R.; Adam, M. K.; Acker, J. P.; Ben, R. N.; Kumar, P.; Narain, R. Trehalose-Based Polyethers for Cryopreservation and Three Dimensional Cell Scaffolds. Biomacromolecules 2020, 21, 1264–1273.

Aohara, T.; Furukawa, J.; Miura, K.; Sakae, T.; Poisson, J. S.; Ben, R. N.; Wilson, P. W.; Satoh, S. Presence of a Basic Secretory Protein in Xylem Sap and Shoots of Poplar in Winter and Its Physicochemical Activities against Winter Environmental Conditions. J. Plant Res. 2019, 132, 655–665. 

Le Tri, D.; Childers, C. L.; Adam, M. K.; Ben, R. N.; Storey, K. B.; Biggar, K. K. Characterization of Ice Recrystallization Inhibition Activity in the Novel Freeze-Responsive Protein Fr10 from Freeze-Tolerant Wood Frogs, Rana Sylvatica. J. Therm. Biol. 2019, 84, 426–430.

Poisson, J. S.; Acker, J. P.; Briard, J. G.; Meyer, J. E.; Ben, R. N. Modulating Intracellular Ice Growth with Cell-Permeating Small-Molecule Ice Recrystallization Inhibitors. Langmuir 2019, 35 (23), 7452–7458. 

Ampaw, A.; Charlton, T. A.; Briard, J. G.; Ben, R. N. Designing the next Generation of Cryoprotectants - From Proteins to Small Molecules. Pept. Sci. 2019, 111 (1), e24086. 

Raju, R.; Merl, T.; Adam, M. K.; Staykov, E.; Ben, R. N.; Bryant, G.; Wilkinson, B. L. N-Octyl (Thio)Glycosides as Potential Cryoprotectants: Glass Transition Behaviour, Membrane Permeability, and Ice Recrystallization Inhibition Studies. Australian Journal of Chemistry. CSIRO 2019, 637–643. 

Adam, M. K.; Jarrett-Wilkins, C.; Beards, M.; Staykov, E.; MacFarlane, L. R.; Bell, T. D. M.; Matthews, J. M.; Manners, I.; Faul, C. F. J.; Moens, P. D. J.; Ben, R. N.; Wilkinson, B. L. 1D Self-Assembly and Ice Recrystallization Inhibition Activity of Antifreeze Glycopeptide-Functionalized Perylene Bisimides. Chem. - A Eur. J. 2018, 24 (31), 7834–7839.

Nagao, M.; Sengupta, J.; Diaz-dussan, D.; Adam, M.; Wu, M.; Acker, J.; Ben, R.; Ishihara, K.; Zeng, H.; Miura, Y. Synthesis of Highly Biocompatible and Temperature-Responsive Physical Gels for Cryopreservation and 3D Cell Culture. ACS Appl. Bio Mater. 2018, 1, 356–366.

Adam, M.K.; Jarrett-Wilkins, C.; Beards, M.; Staykov, E.; MacFarlane, L.R.; Bell, T.D.M.; Matthews, J.M.; Manners, I.; Faul, C.F.J.; Moens, P.D.J.; Ben, R.N.; Wilkinson, B.L. 1D Self-assembly and Ice Recrystallization Inhibition Activity of Antifreeze Glycopeptide-functionalized Perylene bisimides. Chem. Eur. J. 2018, 24(31), 7834.

Weins, J.; Ho, R.; Brassinga, A.K.; Deck, C.A.; Walsh, P.J.; Ben, R.N.; McClymont, K.; Charlton, T.; Evans, A.N.; Anderson, W.G. Biosynthesis of 1alpha-hydroxycorticosterone in the winter skate Leucoraja ocellata: evidence to suggest a novel steroidogenic route. J. Fish Bio. 2017, 91(1), 260.

Giwa, S.; et al. The promise of organ and tissue preservation to transform medicine. Nat. Biotech. 2017, 35(6), 530.

Poisson, J. S.; Briard, J. G.; Turner, T. R.; Acker, J. P.; Ben, R. N. Hydroxyethyl Starch Supplemented with Ice Recrystallization Inhibitors Greatly Improves Cryopreservation. BioProcessing Journal 2017, 15(4).

Adam, M. K.; Hu, Y.; Poisson, J. S.; Pottage, M. J.; Ben, R. N. Wilkinson, B. L. Photoswitchable Carbohydrate-Based Fluorosurfactants as Tuneable Ice Recrystallization Inhibitors. Carbohydr. Res. 2017, 439, 1.

Briard, J. G.; Jahan, S.; Chandran, P.; Allan, D.; Pineault, N.; Ben, R. N. Small-Molecule Ice Recrystallization Inhibitors Improve the Post-Thaw Function of Hematopoietic Stem and Progenitor Cells. ACS Omega 2016, 1(5), 1010.

Capicciotti, C. J.; Mancini, R. S.; Turner, T. R.; Koyama, T.; Alteen, M. G.; Doshi, M.; Inada, T.; Acker, J. P.; Ben, R. N. O-Aryl- Glycoside Ice Recrystallization Inhibitors as Novel Cryoprotectants: A Structure-Function Study. ACS Omega 2016, 1(4), 656.

Briard, J. G.; Fernandez, M.; De Luna, P.; Woo, T. K.; Ben, R. N. QSAR Accelerated Discovery of Potent Ice Recrystallization Inhibitors. Nature Sci. Reports 2016, 6, 26403.

Adam, M. K.; Poisson, J. S.; Hu, Y.; Prasannakumar, G.; Pottage, M. J.; Ben, R. N.; Wilkinson, B. L. Carbohydrate-Based Surfactants as Photocontrollable Inhibitors of Ice Recrystallization. RSC Advances 2016, 6, 39240.

Briard, J. G.; Poisson, J. S.; Turner, T. R.; Capicciotti, C. J.; Acker, J. P.; Ben, R. N. Small Molecule Ice Recrystallization Inhibitors Mitigate Red Blood Cell Lysis During Freezing, Transient Warming and Thawing. Nature Sci. Reports 2016, 6, 23619.

Chow-Shi-Yee, M.; Briard, J. G.; Grondin, M.; Averill-Bates, D. A.; Ben, R. N.; Ouellet, F. Inhibition of Ice Recrystallization and Cryoprotective Activity of Wheat Proteins in Liver and Pancreatic Cells. Protein Sci. 2016, 25, 974.

Capicciotti, C. J.; Kurach, J. D. R.; Turner, T. R.; Mancini, R. S.; Acker, J. P.; Ben, R. N. Small Molecule Ice Recrystallization Inhibitors Enable Freezing of Human Red Blood Cells with Reduced Glycerol Concentrations. Nature Sci. Reports 2015, 5, 9692.

Tonelli, D.; Capicciotti, C. J.; Doshi, M.; Ben, R. N. Inhibiting Gas Hydrate Formation Using Small Molecule Ice Recrystallization Inhibitors. RSC Advances 2015, 5, 21728.

Capicciotti, C. J.; Poisson, J.; Boddy, C. N.; Ben, R. N. Modulation of Antifreeze Activity and the Effect Upon Post-thaw HepG2 Cell Viability after Cryopreservation. Cryobiology 2015, 70, 79.

Briard, J. G.; Ben, R. N. Synthesis of N-(4-methoxybenzyl)-2(alpha-Dglycopyranosyl)acetamide. Proven Methods in Carbohydrate Chemistry, 2015, 3, in press.

Balcerzak, A. K.; Capicciotti, C. J.; Briard, J. G.; Ben, R. N. Designing Ice Recrystallization Inhibitors: from Antifreeze (Glyco)proteins to Small Molecules. RSC Advances 2014, 4, 42682.

Ghobadloo, S. M.; Balcerzak, A. K.; Gargaun, A.; Mironov, G. R.; Capicciotti, C. J.; Briard, J. G.; Ben, R. N.; Berezovski, M. V.. Carbohydrate-based Ice Recrystallization Inhibitors Increase Infectivity and Thermostability of Viral Vectors. Nature Sci. Reports 2014, 4, 5903.

van der Wal, S.; Capicciotti, C. J.; Rontogianni, S.; Ben, R. N.; Liskamp, R. M. J. Synthesis and Evaluation of Linear CuAAC-oligomerized antifreeze neo-glycopeptides. MedChemComm 2014, 5, 1159.

Capicciotti, C. J.; Doshi, M.; Ben, R.N. (2013). Ice Recrystallization Inhibitors: From Biological Antifreezes to Small Molecules (P. Wilson, Ed.). In Recent Developments in the Study of Recrystallization (pp. 177-224). New York, NY: InTech.

Corcilius, L.; Santhakumar, G.; Stone, R. S.; Capicciotti, C. J.; Joseph, S.; Matthews, J. M.; Ben, R. N.; Payne, R. J. Synthesis of peptides and glycopeptides with polyproline II helical topology as potential antifreeze molecules. Bioorganic and Medicinal Chemistry 2013, 21, 3569.

Balcerzak, A. K.; Febbraro, M.; Ben, R. N. The Importance of Hydrophobic Moieties in Ice Recrystallization Inhibitors. RSC Advances 2013, 3, 3232.

Capicciotti, C.; Leclere, M.; Perras, F.; Bryce, D.L.; Paulin, H.; Harden, J.; Ben, R.N. Potent Inhibition of Ice Recrystallization by Low Molecular Weight Carbohydrate-based Surfactants and Hydrogelators. Chemical Science 2012, 3, 1408.

Wilkinson, B. L.; Stone, R. S.; Capicciotti, C. J.; Thaysen-Andersen, M.; Matthews, J. M.; Packer, N. H.; Ben, R. N.; Payne, R. J.  Total Synthesis of Homogeneous Antifreeze Glycopeptides and Glycoproteins.  Angew. Chem. Int. Ed. Eng. 2012, 51, 3606.

Wu, L.K.; Al-Hejazi, A.; Filion, L.; Ben, R.N.; Halpenny, M.; Yang, L.; Giulivi, A.; Allan, D.S. Increased Apoptosis in Cryopreserved Autologous Hematopioetic Progenitor Cells Collected by Apheresis and Delayed Neutrophil Recovery after Transplanation: A Nested Case-controlled Study. Cytotherapy 2012, 14, 205.

Balcerzack, A.; Ferreirra, S.S.; Trant, J.F.; Ben, R.N. Structurally Diverse Disaccharide Analogues of Antifreeze Glycoproteins and their Ability to Inhibit Ice Recrystallization.  Bioorganic and Medicinal Chemistry Letters 2012, 22, 1719.

Chaytor, J.L.; Tokarew, J.M.; Wu, L.K.; Leclere, M.; Tam, R.Y.; Capicciotti, C.J.; Guolla, L.; von Moos, E.; Findlay, C.S.; Allan, D.S.; Ben, R.N. Inhibiting Ice Recrystallization and Optimization of Cell Viability after Cryopreservation. Glycobiology 2012, 22, 123.

Leclere, M.; Kwok, B.; Wu, L.K.; Allan, D.S.; Ben, R.N. C-Linked AFGP Analogues as Novel Cryoprotectants.  Bioconjugate Chemistry 2011, 22, 1804.

Capicciotti,C.; Trant, J.F.; Leclere, M.; Ben, R.N. Synthesis of C-Linked Triazole-Containing AFGP Analogues and Their Ability to Inhibit Ice Recrystallization.  Bioconjugate Chemistry 2011, 22, 605.

Chaytor, J.L.; Ben, R.N. Assessing the Ability of a Short Fluorinated Antifreeze Glycopeptide and a Fluorinated Carbohydrate Derivative to Inhibit Ice Recystallization. Bioorganic and Medicinal Chemistry Letters 2010, 20, 5251.

Wu, L.; Tokarew, J.; Chaytor, J.L.; von Moos, E.; Li,Y.; Palii, C.; Ben, R. N.; Allan, D. Carbohydrate Mediated Inhibition of Recrystallization in Cryopreserved Human Umbilical Cord Blood. Carbohydrate Research 2010, 246, 86.

Younes-Metzler, O.; Ben, R. N.; Giorgi, J. B.  The Absorbption of AFGP Fraction 8 on Dry and Wet Silica.  Colloids and Surfaces B: Biointerfaces 2010, 82, 134.

Tam, R. Y.; Rowley, C. N.; Petrov, I.; Zhang, T.; Afagh, N. A.; Woo, T.; Ben, R. N. Solution Conformation of C-Linked AFGP Analogues and Modulation of Ice Recrystallization Inhibition Activity.  Journal of the American Chemical Society 2009, 131, 15745.

Tam, R.; Czechura, P.; Ferreria, S. S.; Chaytor, J.; Ben, R. N.; Ben, R. N.; "Hydration Index - A Better Parameter for Explaining Small Molecule Hydration in Inhibiting Ice Recrystallization." Journal of the American Chemical Society 2008, 130, 17494.

Czechura, P.; Tam, R.; Dimitrivjevic, E.; Anastasia, A.; Ben, R. n.; "The Importance of Hydration for Inhibiting Ice Recrystallization with C-Linked Antifreeze Glycoproteins." Journal of the American Chemical Society 2008, 130, 2928.

Younes-Metzler, O.; Ben, R. N.; Giorgi, J. B.; "Pattern Formation of Antifreeze Glycoproteins Via Solvent Evaporation." Langmuir 2007, 23, 11355.

Jackmann, J.; Noestheden, M.; Moffat, D.; Pezacki, J.; Findlay, S.; Ben, R. N.; "Assessing Antifreeze Activity of AFGP8 Using Domain Recognition Software." Biochem. Biophys. Res. Commun. 2007, 354, 340.

Liu, S.; Wang, W.; vonMoos, E.; Jackman, J.; Mealing, G.; Monette, R.; Ben, R. N.; "In Vitro Studies of Antifreeze Glycoprotein (AFGP) and a C-Linked AFGP Analogue." Biomacromolecules 2007, 8, 1456.

Bouvet, V. R.; Lorello, G.; Ben, R. N.; "Aggregation of Antifreeze Glycoprotein Fraction 8 and Its Effect on Antifreeze Activity." Biomacromolecules 2006, 7, 565.

Bouvet, V. R.; Ben, R. N.; "An Efficient and Economical Synthesis of Orthogonally Protected a-C-GalactosamineDerivatives." Journal of Organic Chemistry 2006, 71, 3619.

Von Moos, E.; Ben, R. N.; "Recent Advances in the Synthesis of Glycoconjugates." Current Topics in Medicinal Chemistry 2006, 5, 1351. (invited contribution)

Liu, S.; Ben, R. N.; "C-Linked Galactosyl Serine AFGP Analogues as potent Recrystallization Inhibitors." Organic Letters 2005, 7, 2385.

Valenrod, Y.;Myung, J.; Ben, R.N.; "Dynamic Kinetic Resolution Using Immobilized Amine Nucleophiles." Tetrahedron Letters 2004, 45, 2545.

Bouvet, V. R.; Ben, R. N.; "Antifreeze Glycoprotein Analogues: Synthesis, In Vitro Testing and Applications." in R. Roy (ed), Glycomimetics: Modern Synthetic Methodologies. American Chemical Society, Oxford University Press, Washington, D.C., 2004, p.151. (invited contribution)

Wang, W.; Ben, R.N. "Upregulation of Protein Trafficking of AQP2 Attenuates Cold-Induced Osmotic Damage During Cryopreservation" In Vitro Cellular and Developmental Biology-Animal 2004, 40, 67.

Bouvet, V.; Ben, R. N.; "Antifreeze Glycoproteins and Their Role in Cryopreservation" Cell Biochemistry and Biophysics 2003, 39, 133.

Sarno, D.; Murphy, A. V.; DiVirgilio, E. S.; Jones, W. E., Jr.; Ben, R. N.; "Direct Observation of Antifreeze Glycoprotein-Fraction 8 on a Hydrophobic and Hydrophilic Surface Using Atomic Force Microscopy" Langmiur 2003, 19, 4740.

Enaide, A.; Purushotham, M.; Ben, R. N.; "A Serendipitous Discovery of Antifreeze Protein-Specific Activity in C-Linked Antifreeze Glycoprotein Analogues" Cell Biochemistry and Biophysics 2003 38, 115.

Eniade, A.; Ben, R.N.; "Fully Convergent Solid Phase Synthesis of Antifreeze Glycoprotein Analogues." Biomacromolecules 2001, 2, 557.

Eniade, A.; Murphy, A.V.; Landreau, G.; Ben, R.N.; "A General Synthesis of Structurally Diverse Building Blocks for Preparing Mimics of Antifreeze Glycoproteins" Bioconjugate Chemistry 2001, 12, 817.

Ben, R. N.; "Antifreeze Glycoproteins: Preventing the Growth of Ice" ChemBioChem 2001, 2, 161.

Ben, R. N.; Eniade, A. A.; Hauer, L.; "Synthesis of a C-Linked Antifreeze Glycoprotein (AFGP) Mimic: Probes for Investigating the Mechanism of Action." Organic Letters 1999, 1, 1759.

Swanson, J. E.; Ben, R. N.; Burton, G. W.; Parker, R. S. "Urinary Excretion of 2,7,8-Trimethyl-2-(b-carboxyethyl)-6-hydroxychroman is the Major Route of Elimination of g-Tocopherol in Humans." Journal of Lipid Research, 1999, 40, 665.

Ben, R. N.; Durst, T.; "Synthesis of Optically Active a-Amino Esters via Dynamic Kinetic Resolution (DKR): a Mechanistic Study." Journal of Organic Chemistry 1999, 64, 7700.

Arya, P.; Ben, R. N.; Qin, H.; "Remote Asymmetric Induction: Synthesis of a-Galactoserine and Homo-Galactoserine Derivatives by Electrophilic Amination." Tetrahedron Letters, 1998, 39, 6131.

Ben, R. N.; Orellana, R.; Arya, P. "A Stereoselective Synthesis of Carbon-Linked Analogues of a- and b-Galactosyl Serine Glycoconjugates Using Asymmetric Enolate Methodology." Journal of Organic Chemistry 1998, 63 4817.

O’Meara, J.; Gardee, N.;? Jung, M.; Ben, R. N.; Durst, T.; "Enantioselective Synthesis of b-Dibenzyl Alchohols via a Dynamic Kinetic Resolution of a-Halo Acids." Journal of Organic Chemistry 1998, 63, 3117.

Arya. P.; Ben, R. N.; "Combinatorial Chemistry for the Synthesis of Carbohydrate Libraries." Angew. Chem. Int. Ed. Engl. 1997, 36, 1280.

Lautens, M.; Ben, R.N.; Delanghe, P.H.M.; "Allyl 1,1-Heterobimetallic Reagents: Their Preparation and Reacivity Profile." Tetrahedron 1996, 52, 7221.

Koh, K.; Ben, R.N.; Durst, T.; "A Facile Synthesis of Optically Active C-2 Symmetric 2,5-Disubstituted Pyrrolidines and other b,b'-Dihydroxyamines." Tetrahedron Letters 1994, 35, 375.

Ben, R.N.; Breau, L.; Bensimon, C.; Durst, T.; "Unusual Stereochemical Results in the Reaction of a-Lithio Derivatives of Bicyclic sulfoxides." Tetrahedron 1994, 50, 6061.

Durst, T.; Ben, R.N.; "Ethyldiphenylsulfonium Tetrafluoroborate." Encyclopedia of Reagents for Organic Synthesis (EROS), Wiley-Interscience, New York, New York, 1994, 2438.

Durst, T.; Ben, R.N.; "Isopropyldiphenylsulfonium Tetrafluoroborate." Encyclopedia of Reagents for Organic Synthesis (EROS), Wiley-Interscience, New York, New York, 1994, 2921.

Koh, K.; Ben, R.N.; Durst, T.; "Reaction of (R)-Pantolactone Esters of a-Bromoacids with Amines. A Remarkable Synthesis of Optically Active a-Amino Esters." Tetrahedron Letters 1993, 34, 4473.

Durst, T.; Breau, L.; Ben, R.N.; "Sulfonium Ylides. Application to the Synthesis of Optically Active Epoxides." Phosphorus, Sulfur and Silicon 1993, 74, 215.