Pu Xia (Sharp)
Affiliation
Postdoctoral Fellow
Email: xiapunju@gmail.com
Research interests
Toxicogenomics
Predictive Toxicology
Ecotoxicology
Transcriptomics
Bio
I am a postdoctoral fellow at the University of Ottawa. I got my Bachelor (2008-2012) and PhD degree (2012-2018) at the School of the Environment, Nanjing University. My research has been focused on omics-based mechanistic toxicology of environmental chemicals and mixtures.
Research project
1) Cross-species comparison of transcriptomics in human, avian and fish neural cell lines exposed to MeHg
2) Comparison of transcriptomics of Per and Polyfluoroalkyl Substances (PFASs) in human liver cell lines and liver stem cells
3) Toxicogenomic assessment of complex chemical signatures in avian species
4) Omics data for AOP network-based chemical assessment.
Selected Publications
1. Xia P, Ying P, Fang W, Tian M, Shen Y, Ma C, Crump D, O'Brien JM, Shi W, Zhang X. (2021) Cross-Model Comparison of Transcriptomic Dose-Response of Short-Chain Chlorinated Paraffins. Environ. Sci. Technol. DOI: 10.1021/acs.est.1c00975.
2. Zahaby Y#, Xia P#, Crump D, Provencher J, Thomas P, Pauli B, Braune B, Franckowiak R, Gendron M, Savard G, Sarma S, Mallory M, and O'Brien JM. (2021) ToxChip PCR Arrays for Two Arctic-Breeding Seabirds: Applications for Regional Environmental Assessments. Environ. Sci. Technol. DOI: 10.1021/acs.est.1c00229. (# co-1st)
3. Xia P, Crump D, Chiu S, Chan HM, O'Brien JM. (2020) Toxicogenomic Assessment of Complex Chemical Signatures in Double-Crested Cormorant Embryos from Variably Contaminated Great Lakes Sites. Environ. Sci. Technol. 54, (12), 7504-7512.
4. Wang P#, Xia P#, Yang J, Wang Z, Peng Y, Shi W, Villeneuve DL, Yu H, Zhang X. (2018) A Reduced Transcriptome Approach to Assess Environmental Toxicants Using Zebrafish Embryo Test. Environ. Sci. Technol. 52, (2), 821-830. (# co-1st)
5. Xia P, Zhang X, Zhang H, Wang P, Tian M, Yu H. (2017) Benchmarking Water Quality from Wastewater to Drinking Waters Using Reduced Transcriptome of Human Cells. Environ. Sci. Technol. 51, (16), 9318-9326.
6. Xia P, Zhang X, Xie Y, Guan M, Villeneuve DL, Yu H. (2016) Functional Toxicogenomic Assessment of Triclosan in Human HepG2 Cells Using Genome-Wide CRISPR-Cas9 Screening. Environ. Sci. Technol. 50, (19), 10682-10692. (Front Cover, ES&T Best Paper Award, ACS Editor’ Choice)
7. Peng Y#, Xia P#, Zhang J, Villeneuve DL, Zhang J, Wang Z, Wei S, Yu H, Zhang X. (2016) Toxicogenomic Assessment of 6-OH-BDE47-Induced Developmental Toxicity in Chicken Embryos. Environ. Sci. Technol. 50, (22), 12493-12503. (# co-1st)