Joseph Wai-Hin Leung

Affiliation

Postdoctoral Fellow
Email: wleung2@uottawa.ca 

Research interests

Neurogenesis
Neurodevelopment
Environmental toxicology

Bio

I am a postdoctoral fellow in Dr. Laurie Chan’s lab in the Department of Biology at the University of Ottawa. I got my PhD in neuroscience in the Department of Medicine at the University of Hong Kong. Before joining Chan lab, I had my postdoctoral training in the Department of Surgery at the University of Toronto. My research interest is neurogenesis and neurodevelopment. I am particularly interested in studying the relationship between impaired neurogenesis and different kinds of neurological disorders. My current research focuses on the impact of prenatal exposure to low-dose methylmercury on early neurodevelopment.

Publications

Leung, J. W.-H., Cheung, R. T.-F. (2021) Melatonin attenuates microglial activation and improves neurological functions in rat model of collagenase-induced intracerebral hemorrhage. Melatonin Research, 4(2), 360-376

Leung, J. W.-H., Cheung, K.-K., Ngai, S. P.-C., Tsang, H. W.-H., & Lau, B. W.-M. (2020). Protective effects of melatonin on neurogenesis impairment in neurological disorders and its relevant molecular mechanisms. International Journal of Molecular Sciences, 21(16), 5645.

Cheung, K.-K., Fung, T. K.-H., Mak, J. C. W., Cheung, S.-Y., He, W., Leung, J. W.-H, Lau, B. W. M., & Ngai, S. P. C. (2020). The acute effects of cigarette smoke exposure on muscle fiber type dynamics in rats. PloS One, 15(5), e0233523.

Leung, J. W.-H., Lau, W. K.-W., Lau, B. W.-M., & Yee, B. K. (2019). A commentary on the therapeutic potential of melatonin and its analogues in CNS conditions. In P. Á. Gargiulo & H. L. Mesones Arroyo (Eds.), Psychiatry and Neuroscience Update: From Translational Research to a Humanistic Approach—Volume III (pp. 177–186). Springer International Publishing. (Chapter)

Wong, R., Abussaud, A., Leung, J. W.-H, Xu, B.-F., Li, F.-Y., Huang, S., Chen, N.-H., Wang, G.-L., Feng, Z.-P., & Sun, H.-S. (2018). Blockade of the swelling-induced chloride current attenuates the mouse neonatal hypoxic-ischemic brain injury in vivo. Acta Pharmacologica Sinica, 39(5), 858–865.

Ho, J., He, W., Chan, M. T. V., Tse, G., Liu, T., Wong, S. H., Leung, C. C. H., Wong, W. T., Tsang, S., Zhang, L., Chan, R. Y. P., Gin, T., Leung, J. W.-H, Lau, B. W. M., Wu, W. K. K., & Ngai, S. P. C. (2017). Eosinophilia and clinical outcome of chronic obstructive pulmonary disease: A meta-analysis. Scientific Reports, 7(1), 13451.

Po, K. K.-T.#, Leung, J. W.-H.#, Chan, J. N.-M., Fung, T. K.-H., Sánchez-Vidaña, D. I., Sin, E. L.-L., So, K.-F., Lau, B. W.-M., & Siu, A. M.-H. (2017). Protective effect of Lycium Barbarum polysaccharides on dextromethorphan-induced mood impairment and neurogenesis suppression. Brain Research Bulletin, 134, 10–17. (# Co-first authors)

Leung, J. W.-H., Lau, B. W.-M., Chan, V. S.-F., Lau, C.-S., & So, K.-F. (2016). Abnormal increase of neuronal precursor cells and exacerbated neuroinflammation in the corpus callosum in murine model of systemic lupus erythematosus. Restorative Neurology and Neuroscience, 34(3), 443–453.