Yueting Shao

Yueting Shao

 

 

 

Affiliation

Post-Doctoral Fellow
University of Ottawa
Email:  ysha2@uottawa.ca

Research interests

Methylmercury
Primary culture
Proteomics
Neurotoxicity
Parkinson’s disease

 

 

Bio

My background is in Medicine and Pathophysiology.  I am interested in doing research in the field between health and environmental studies. The diversified research environment in Dr. Chan’s group has driven my aspirations. Working towards a degree in environment studies will complement my Health Science background and will not only expand my intellectual horizons, but will also help me to conduct multi-disciplinary environmental health research. Studying in Canada has exposed me to new research fields and different ways of thinking that result from collaborating in a multi-cultural environment.

Research project

My project investigates the effects and mechanisms of Methylmercury on the neurotoxicity in different species (mouse primary cultures, dopaminergic neuron cells and marmoset brain tissues), particularly in the substantia nigra and the striatum-dopamine pathway. This research applies toxicological theories to environmental health and is essential to understanding the relationship between exposure to environmental chemicals and neurological conditions such as Parkinson’s disease and other neurodegenerative diseases.

Publications

  • Shao Y, Liu Y, Shao C, Hu J, Li X, Li F, Zhang L, Zhao D, Sun L, Zhao X, Kopecko DJ, Kalvakolanu DV, Li Y, Xu DQ. Enhanced tumor suppression in vitro and in vivo by co-expression of survivin-specific siRNA and wild-type p53 protein. Cancer Gene Ther. 2010, 17(12):844-854.
  • Shao Yueting,  Xu Deqi, Liu Yanan, Li Xiaojie, Shao Chen, Li Yang, Zhao Xuejian. Attenuated Salmonella targeted carrying the plasmid co-expressed p53 and siRNA-survivin for prostate cancer therapy in vivo. Chinses Journal of Clinical Oncology. 2008, 35(9):528-531.
  • Shao YT, Zhang L, Ji K, Li Y, Zhao XJ. The Cloning of Mouse GRIM-19 Gene and its Apoptosis Effects on rm-1 Cells. Journal of Basic &Clinical Medicine. 2008, 28(1):13-17. (Chinese Journal)
  • SHAO Yue-ting, LIU Ya-nan, SHAO Chen, Ji Kun, Li Xiao-jie, Li Feng, Zhang Ling, Zhao Dan, Li Yang, Xu De-qi, Hu Jia-di, Zhao Xue-jian. Construction of vectors encoding both wide type p53 protein and siRNA-mdm2 and their expressions in PC-3 cells. Journal of Jilin University, (Medicine Edition). 2010, 36(1):30-34. (Chinese Journal)
  • LIU Ya-nan, SHAO Yue-ting, LI Xiao-jie, JI Kun, SHAO Chen, LI Yang, ZHAO Xue-jian. Effect of diterpenoid B derived from rabdosia excise on cell cycle of mouse prostatic cancer cell line. Chinese Journal of Pathophysiology. 2008, 24(10): 1916 -1921.
  • LI Feng, LI Shuai, GUO Li- rong, SHAO Yue-ting, JI Kun, LI Yang, ZHAO Xue-jian. Effect of estrogen receptor 2 on the cell proliferation in prostate cancer cell line PC-3M. Chinese Journal of Pathophysiology. 2009, 25(4):656-660.
  • Ling Zhang, Lifang Gao, Yang Li,Guimiao Lin, Yueting Shao, Kun Ji, Hao Yu, Jiadi Hu, Dhananjaya V. Kalvakolanu, Dennis J. Kopecko, Xuejian Zhao, and De-Qi Xu. Effects of Plasmid-Based Stat3-Specific Short Hairpin RNA and GRIM-19 on PC-3M Tumor Cell Growth. Clinical Cancer Research. 2008, 14(2): 559-568.
  • Li X, Zhang L, Shao Y, Liang Z, Shao C, Wang B, Guo B, Li N, Zhao X, Li Y, Xu D. Effects of a human plasma membrane-associated sialidase siRNA on prostate cancer invasion. Biochem Biophys Res Commun. 2011, 416(3-4):270-276.
  • Ji K, Wang B, Shao YT, Zhang L, Liu YN, Shao C, Li XJ, Li X, Hu JD, Zhao XJ, Xu DQ, Li Y, Cai L. Synergistic suppression of prostatic cancer cells by coexpression of both murine double minute 2 small interfering RNA and wild-type p53 gene in vitro and in vivo. J Pharmacol Exp Ther. 2011, 338(1):173-183.

Book Chapter

  • DQ Xu, L Zhang, DJ Kopecko, L Gao, Y Shao, B Guo, L Zhao. Bacterial delivery of siRNAs: a new approach to solid tumor therapy. Methods Mol Biol. 2009, 487: 161-87. Press Inc. Totowa NJ.