Sailendra Nath Sarma
Affiliation
Postdoctoral Fellow
Email: ssarm2@uottawa.ca
Research interests
Neurotoxicity
Polycyclic Aromatic Hydrocarbons (PAHs)
Biomarkers
Toxicogenomics
Bio
I have great interest in the study of the toxicity of volatile organic compounds (VOCs) and polycyclic aromatic hydrocarbons (PAHs). I was previously working in the field of toxicogenomics, trying to gain insights on the mechanisms of toxicity of volatile organic compounds (VOCs) on human leukemia cells. I have accrued experience in developing transgenic stem cells, and in toxicogenomic research (microarray, comet assay and a range of chromatography) for the assessment of toxicity of chemicals. Presently, my research focused on the neurotoxicity due to PAHs exposure.
Publications
1) Sailendra Nath Sarma, Taejun Han, Jae-Chun Ryu and Youn-Jung Kim *: Genome-wide analysis of dichloromethane-regulated genes in human promyelocytic leukemia HL-60 cells. BioChip Journal 6: 65-72 (2012)
2) Sailendra Nath Sarma, Youn-Jung Kim and Jae-Chun Ryu*: Differential gene expression profiles of human promyelocytic leukemia cell lines exposed to benzene and its metabolites. Environmental Toxicology and Pharmacology 32: 285-295 (2011)
3) Sailendra Nath Sarma, Youn-Jung Kim, Mee Song and Jae-Chun Ryu*: Induction of apoptosis in human leukemia cells through the production of reactive oxygen species and activation of HMOX1 and Noxa by benzene, toluene, and o-xylene. Toxicology 280: 109-117 (2011)
4) Sailendra Nath Sarma, Youn-Jung Kim, Mee Song and Jae-Chun Ryu*: Genome-wide identification of ethylbenzene and trichloroethylene-regulated genes in human promyelocytic leukemia HL-60 cells. BioChip Journal 5, 19-26 (2011)
5) Sailendra Nath Sarma, Youn-Jung Kim and Jae-Chun Ryu*: Gene expression profiles of human promyelocytic leukemia cell lines exposed to volatile organic compounds. Toxicology 271: 122-130 (2010)
6) Sailendra Nath Sarma, Youn-Jung Kim and Jae-Chun Ryu*: Differential gene expression profiling in human promyelocytic leukemia cells treated with benzene and ethylbenzene. Molecular & Cellular Toxicology 4: 267-277 (2008)
7) Sailendra Nath Sarma, Youn-Jung Kim, Hee-Kyung Jeon and Jae-Chun Ryu*: Identification of immune responsive genes on benzene, toluene and o-xylene in Jurkat cells using 35 k human oligomicroarray. Molecular & Cellular Toxicology 2: 229-235 (2006)
Presentations
Neurotoxic Effect of the Alkay Polycyclic Aromatic Hydrocarbons in Human Neuroblastoma Cells. CREATE-Summer workshop, Edmonton. July/2015
Neurotoxic Effect of the Alkay Polycyclic Aromatic Hydrocarbons in Human Neuroblastoma Cells. Society of Toxicology Canada, Ottawa. December/2015