Publications & Patents (2005-present)
"Mesomeric Acceleration Counters Slow Initiation of Ruthenium-CAAC Catalysts for Olefin Metathesis." X. Ou, G. Occhipinti, E.-J. Y. Boisvert, V. R. Jensen,* D. E. Fogg.* ACS Catal., 2023, 13, 5315-5325.
"Rapid Aerial Oxidation of Ruthenium-Dithiocatcholate Catalysts: A Challenge to Stereoselective Olefin Metathesis." E.-J. Y. Boisvert, H. Max, D. E. Fogg.* ACS Catal., 2023, 13, 2885-2891.
"Water-Accelerated Decomposition of Olefin Metathesis Catalysts." C. O. Blanco, D. E. Fogg.* ACS Catal., 2023, 13, 1097-1102.
"The Janus Face of High Trans-Effect Carbenes in Olefin Metathesis: Gateway to Both Productivity and Decomposition." G. Occhipinti,* D. L. Nascimento, M. Foscato, D. E. Fogg,* V. R. Jensen.* Chem. Sci, 2022, 13, 5107-5117. Hot Article, Front Cover.
"Toward E-Selective Olefin Metathesis: Computational Design and Experimental Realization of Ruthenium Thio-Indolate Catalysts." I. Reim, G. Occhipinti, K. W. Törnroos, D. E. Fogg, V. R. Jensen.* Topics in Catalysis, 2022, 448-461. (Invited for Topical Issue "Computational Catalysis: a Land of Opportunities"; Guest Editor Odile Eisenstein).
"Bimolecular Coupling in Olefin Metathesis: Correlating Structure and Decomposition for Leading and Emerging Ruthenium-Carbene Catalysts." D. L. Nascimento, M. Foscato, G. Occhipinti, V. R. Jensen,* D. E. Fogg*, J. Am. Chem. Soc., 2021, 143, 11072-11079.
"Routes to High-Performing Ru-Iodide Catalysts for Olefin Metathesis: Phosphine Lability Is Key to Efficient Halide Exchange." C.O. Blanco, D.L. Nascimento, D.E. Fogg,* Organometallics, 2021, 40, 1811-1816.
"The Impact of Water on Ru-Catalyzed Olefin Metathesis: Potent Deactivating Effects Even at Low Water Concentrations." C.O. Blanco, J. Sims, D.L. Nascimento, A.Y. Goudreault, S.N. Steinmann, C. Michel,* D.E. Fogg,* ACS Catal., 2021, 11, 893-899.
"Challenging Metathesis Catalysts with Nucleophiles and Brønsted Base: The Stability of State-of-the-Art Catalysts to Attack by Amines." D. L. Nascimento, I. Reim, M. Foscato, V. R. Jensen, D. E. Fogg*, ACS Catal. 2020, 10, 19, 11623-11633.
"Protection of Ruthenium Olefin Metathesis Catalysts by Encapsulation in a Self-Assembled Resorcinarene Capsule." L.J. Jongkind, M. Rahimi, D. Poole, S.J. Ton, D.E. Fogg,* J.N.H. Reek.* ChemCatChem, 2020, 12, 4019-4023.
"Hydroxide-Induced Catalyst Deactivation in Olefin Metathesis." A.Y. Goudreault, D.M. Walden, D.L. Nascimento, A.G. Botti, S.N. Steinmann, C. Michel,* D.E. Fogg.* ACS Catal., 2020, 10, 3838-3843.
"Origin of the Breakthrough Productivity of Ruthenium-CAAC Catalysts in Olefin Metathesis (CAAC = Cyclic Alkyl Amino Carbene)." D.L. Nascimento, D.E. Fogg.* J. Am. Chem. Soc. 2019, 141, 19236-19240.
"The Impact of Oxygen on Leading and Emerging Ru-Carbene Catalysts for Olefin Metathesis: An Unanticipated Correlation Between Robustness and Metathesis Activity." S.J. Ton, D.E. Fogg.* ACS Catal. 2019, 9, 11329-11334.
"Integrating Activity with Accessibility in Olefin Metathesis: An Unprecedentedly Reactive Ruthenium-Indenylidene Catalyst." D.L. Nascimento, A. Gawin, R. Gawin, P.A. Gunka, J. Zachara, K. Skowerski, D.E. Fogg.* J. Am. Chem. Soc. 2019, 141, 10626-10631.
"High-Yield Synthesis of a Long-Sought, Labile Ru-NHC Complex, and Its Application to the Concise Synthesis of Second-Generation Metathesis Catalysts." C.S. Day, D.E. Fogg.* Organometallics, 2018, 37, 4551-4555. ACS Editor's Choice; Open Access.
* #1 research article download for Dec. 2018 and Jan. 2019.
"Rapid Decomposition of Olefin Metathesis Catalysts by a Truncated N-Heterocyclic Carbene (NHC): Efficient Catalyst Quenching and NHC Vinylation." S.A. Rufh, A.Y. Goudreault, M. Foscato, V.R. Jensen, D.E. Fogg.* ACS Catal. 2018, 8, 11822-11826.
"Bimolecular Coupling as a Vector for Decomposition of Fast-Initiating Olefin Metathesis Catalysts." G.A. Bailey, M. Foscato, C.S. Higman, C.S. Day, V. Jensen, D.E. Fogg.* J. Am. Chem. Soc. 2018, 140, 6931-6944.
"Merrifield Resin-Assisted Routes to Second-Generation Metathesis Catalysts." D.L. Nascimento, D.E. Fogg.* Catal. Sci. Technol. 2018, 8, 1535-1544.
"Chelate-Assisted Ring-Closing Metathesis: A Strategy for Accelerating Macrocyclization at Ambient Temperatures." C.S. Higman,^ D.L. Nascimento,^ B.J. Ireland, S.A. Audorsch, G.A. Bailey, R. McDonald, D.E. Fogg.* J. Am. Chem. Soc. 2018, 140, 1604-1607.(^ = Equal contributions).
"Decomposition of Olefin Metathesis Catalysts by Bronsted Base: Metallacyclobutane Deprotonation as a Primary Deactivating Event." G.A. Bailey, J.A. Lummiss, M. Foscato, G. Occhipinti, R. McDonald, V. Jensen, D.E. Fogg.* J. Am. Chem. Soc. 2017, 139, 16446-16449.
"Synthesis and Dynamic Behaviour of a Dimeric Ruthenium Benzylidene Complex Bearing a Truncated N-Heterocyclic Carbene Ligand." C.S. Higman, S.A. Rufh, R. McDonald, D.E. Fogg.* J. Organomet. Chem. 2017, 847, 162-166 (special issue in honour of John Gladysz). Highlighted on All Things Metathesis blog.
"Overcoming Catalyst Decomposition in Acrylate Metathesis: Polyphenol Resins as Enabling Agents for Phosphine-Stabilized Metathesis Catalysts." A. G. Santos,^ G.A. Bailey,^ E. N. dos Santos* and D. E. Fogg.* ACS Catalysis, 2017, 7, 3181-3189; ACS Editor's Choice. (^ = Equal contributions).
"A General Decomposition Pathway for Phosphine-Stabilized Metathesis Catalysts: Lewis Donors Accelerate Methylidene Abstraction." W.L. McClennan, S.A. Rufh, J.A. M. Lummiss, D.E. Fogg.* J. Am. Chem. Soc. 2016, 138, 14668-14677.
"Catalyst Decomposition during Olefin Metathesis Yields Isomerization-Active Ruthenium Nanoparticles." C.S. Higman, A.E. Lanterna, M.L. Marin, J.C. Scaiano*, D.E. Fogg.* ChemCatChem. 2016, 8, 2446-2449.
(Front Cover).
"Confronting Neutrality: Key Parameters in the Successful Analysis of Organometallic Complexes by MALDI Mass Spectrometry." G.A. Bailey, D.E. Fogg.* ACS Catalysis, 2016, 6, 4962-4971; Open Access.
"Sterically Driven Olefin Metathesis: The Impact of Alkylidene Substitution on Catalyst Activity." J.A.M. Lummiss, F.A. Perras, R. McDonald, D.L. Bryce,* D.E. Fogg.* Organometallics, 2016, 35, 691-698.
"Tandem Catalysis versus One-Pot Catalysis: Ensuring Process Orthogonality in the Transformation of Essential-Oil Phenylpropenoids into High-Value Antioxidants via Olefin Isomerization-Metathesis." C.S. Higman, M. P. de Araujo, D.E. Fogg.* Cat. Sci. Technol. 2016, 6, 2077-2084; back cover.
"Olefin Metathesis at the Dawn of Uptake in Pharmaceutical and Specialty Chemicals Manufacturing." C.S. Higman, J.A.M. Lummiss, D.E. Fogg.* Angew. Chem. Int. Ed., 2016, 55, 3552-3565. Invited review.
"The Divergent Effects of Strong NHC Donation in Catalysis." J.A.M. Lummiss, C.S. Higman, D.L. Fyson, R. McDonald, D.E. Fogg.* Chem. Sci. 2015, 6, 6739-6746.
"Decomposition of a Phosphine-Free Metathesis Catalyst by Amines and Other Nitrogen Bases: Metallacyclobutane Deprotonation as a Major Deactivation Pathway." B. J. Ireland, B. T. Dobigny, D. E. Fogg. ACS Catal. 2015, 4690-4698.
Highlighted on "All Things Metathesis" blog.
"Acrylate Metathesis via the Second-Generation Grubbs Catalyst: Unexpected Pathways Enabled by a PCy3-Generated Carbanion." G. A. Bailey, D. E. Fogg. J. Am. Chem. Soc. 2015, 137, 7318-7321.
"Donor-Induced Decomposition of the Grubbs Catalysts: An Intercepted Intermediate." J. A. M. Lummiss, W. L. McClennan, R. McDonald, D. E. Fogg,* Organometallics 2014, 33, 6738-6741.
"Isotopic probes for ruthenium-catalyzed olefin metathesis." J.A.M. Lummiss, Adrian G. G. Botti, Deryn E. Fogg,* Catal. Sci. Technol., 2014, 4, 4210-4218.
(invited for "Mechanistic Studies in Catalysis" issue). Selected for inside cover; "Hot paper".
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"Operation of the Boomerang Mechanism in Olefin Metathesis Reactions Promoted by the Second-Generation Hoveyda Catalyst." Jennifer M. Bates, Justin A. M. Lummiss, Gwendolyn A. Bailey, Deryn E. Fogg,* ACS Catal 2014, 4, 2387-2394. Highlighted on "All Things Metathesis" blog.
"Amine-Mediated Degradation in Olefin Metathesis Reactions that Employ the Second-Generation Grubbs Catalyst." J.A.M. Lummiss, B.J. Ireland, J.M. Sommers, D.E. Fogg,* ChemCatChem 2014, 6, 459-463.
"Ring-Closing Metathesis: A Critical Review." B.J. van Lierop, J.A.M. Lummiss, D.E. Fogg*, Olefin Metathesis: Theory and Practice, K. Grela, Ed., Wiley, Chapter 2, pp. 85-152.
"Isomerization During Olefin Metathesis: An Assessment of Potential Catalyst Culprits." C.S. Higman, L. Plais, D.E. Fogg,* ChemCatChem 2013, 5, 3548-3551.
"On the Compatibility of Ruthenium Metathesis Catalysts with Secondary Phosphines." B.J. van Lierop, D.E. Fogg,* Organometallics 2013, 32, 7245-7248.
"Exploring the Variable Hapticity of the Arylamide Ligand: Access to σ-Amidophenyl and π-Cyclohexadienylimine Structures." B.J. Ireland, R. McDonald, D.E. Fogg,* Organometallics 2013, 32, 4723-4725.
"Chemical Plants: High-Value Molecules from Essential Oils." J.A.M. Lummiss, K.C. Oliveira, A.M.T. Pranckevicius, A.G. Santos, E.N. dos Santos, D.E. Fogg, J. Am. Chem. Soc. 2012, 134, 18889-18891. See ACS press release.
"High-Yield, High-Purity Routes to Second-Generation Ru Metathesis Catalysts from Commercially Available Precursors." B.J. van Lierop, A.M. Reckling, J.A.M. Lummiss, D.E. Fogg*, ChemCatChem, 2012, 4, 2020-2025 (selected for inside cover).
"A Ru-Isocyanate Initiator for Fast, Living Ring-Opening Metathesis Polymerization at Ambient Temperatures." S. Monfette, J. Marleau-Gillette, J.C. Conrad, R. McDonald, D.E. Fogg*, Dalton Trans. 2012, 41, 14476-14479.
"Targeting an Achilles Heel in Olefin Metathesis: A Strategy for High-yield Synthesis of Second-generation Grubbs Methylidene Catalysts." J.A.M. Lummiss, N.J. Beach, J. Smith, D.E. Fogg*, Catal. Sci. Technol., 2012, 2, 1630-1632. (designated as Hot Article)
"Decomposition of Grubbs Catalysts by Excess Methoxide: Novel Methoxyhydride Complexes of Ruthenium." N.J. Beach, J.A.M. Lummiss, J.M. Bates, D.E. Fogg*, Organometallics 2012, 31, 2349-2356. Highlighted on "All Things Metathesis" blog.
"Ethylene-Promoted vs. Ethylene-Free Enyne Metathesis." A.G.D. Grotevendt, J.A.M. Lummiss, M.L. Mastronardi, D.E. Fogg*, J. Am. Chem. Soc. 2011, 133, 15918-15921.
"A Reactive Ru-Binaphtholate Building Block with Self-Tuning Hapticity." J.M. Blacquiere, C.S. Higman, R. McDonald, D.E. Fogg*, J. Am. Chem. Soc. 2011, 133, 14054-14062.
"Expanding the "ROMP Toolbox" for Tissue Engineering: Assessing the Design Criteria for Ru-Pseudohalide Initiators." S. Monfette, J.C. Conrad, K.D. Camm, D.E. Fogg*, Poly. Prepr., 2011, 52-53.
"Unprecedentedly Strong Binding of Dinitrogen at Ruthenium." J.M. Blacquiere, C.S. Higman, S.I. Gorelsky, N.J. Beach, S.J. Dalgarno, D.E. Fogg*, Angew. Chem. Int. Ed. 2011, 50, 916-919.
The Future, Faster: Using High-Throughput Experimentation to Accelerate Discovery in Organometallic Chemistry." S. Monfette, J. M. Blacquiere, D.E. Fogg*, Organometallics 2011, 30, 36-42. (invited contribution for "The Future of Organometallic Chemistry").
"Hydrogenolysis versus Methanolysis of First- and Second-Generation Grubbs Catalysts: Rates, Speciation, and Implications for Tandem Catalysis." N.J. Beach, K.D. Camm, D.E. Fogg,* Organometallics 2010, 29, 5450-5455 (invited: special issue in honour of Dietmar Seyferth).
"Ring-Closing Metathesis Synthesis of Medium and Large Rings: Challenges and Implications for Sustainable Synthesis." S. Monfette, D.E. Fogg*, in Green Metathesis Chemistry, NATO Adv. Chem. Series; V. Dragutan, E. Finkelshtein, Eds, 2010.
"Getting RCM Off the Bench: Reaction-Reactor Matching Transforms Metathesis Efficiency in the Continuous-Flow Assembly of Large Rings." S. Monfette, M. Eyholzer, D.M. Roberge*, D.E. Fogg*, Chem. Eur. J. 2010, 16, 11720-11725. (Collaboration with LONZA, Switzerland)
"Integrating the Schrock and Grubbs Catalysts: Ru-Binaphtholate Catalysts for Olefin Metathesis." J.M. Blacquiere, R. McDonald, D.E. Fogg*, Angew. Chem. Int. Ed. 2010, 49, 3807-3810.
"Monitoring Ring-Closing Metathesis: Limitations on the Utility of Routine 1H NMR Spectroscopy." S. Monfette, A.K. Crane, J.A. Duarte Silva, G.A. Facey, E.N. dos Santos, M. Araujo, D.E. Fogg,* Inorg. Chem. Acta 2010, 363, 481-486 (special issue in honour of Paul Pregosin)
2009
"Geometric and Electronic Structure of a C1-Symmetric Ru-Aryloxide Metathesis Catalyst: An Experimental and Computational Study." M.W. Kotyk, S.I. Gorelsky, J.C. Conrad, C. Carra, D.E. Fogg*, Organometallics 2009, 28, 5424-5431.
"Synthetic Neoglycopolymer-Recombinant Human Collagen Hybrids As Biomimetic Crosslinking Agents in Corneal Tissue Engineering." K. Merrett, W. Liu, D. Mitra, K.D. Camm, C.R. McLaughlin, Y. Liu, M.A. Watsky, F. Li, M. Griffith, D.E. Fogg*, Biomaterials, 2009 30 5403-5408.
"Equilibrium Ring-Closing Metathesis." S. Monfette, D.E. Fogg*, Chem. Rev. (invited review: Thematic Issue on Carbenes in Chemistry), 2009, 109, 3783-3816.
"Electronic Effects of the Anionic Ligands in Ru-Catalyzed Olefin Metathesis." S. Monfette, K.D. Camm, S. Gorelsky, D.E. Fogg*, Organometallics, 2009, 28, 944-946.
"Carbonyl-Amplified Catalyst Performance: Balancing Stability against Activity for Five-Coordinate Ruthenium Hydride and Hydridocarbonyl Catalysts." N.J. Beach, J.M. Blacquiere, S.D. Drouin, D.E. Fogg*, Organometallics, 2009, 28, 441-447.
"Dissecting Out the Effect of Ru-OAr Bonding in a Five-Coordinate Complex of Ruthenium (II)." S. Monfette, J.A. Duarte Silva, S.I. Gorelsky, S.J. Dalgarno, E.N. dos Santos, M.H. Araujo, D. E. Fogg*, Can. J. Chem. 2009, 87, 361-367 (special issue in honour of Dick Puddephatt).
2008
"Time as a Dimension in High-Throughput Homogeneous Catalysis." J.M. Blacquiere, T. Jurca, J. Weiss, D.E. Fogg*, Adv. Syn. Catal. 2008, 350, 2849-55.
"Inside the Black Box: Perspectives on Transformations in Catalysis" (Strem Award Lecture; invited cover article), D.E. Fogg*, Can. J. Chem., 2008, 86, 931-941.
"The Mechanism of Olefin Hydrogenation Catalyzed by RuHCl(L)(PR3)2 Complexes (L=CO, PR3)." C.N. Rowley, H.M. Foucault, T.K. Woo*, D.E. Fogg*, Organometallics, 2008, 27, 1661-1663.
"Convenient Routes to Versatile Ruthenium Hydridocarbonyl Catalysts Containing Electron-Rich Ancillary Ligands." N.J. Beach, U.L. Dharmasena, S.D. Drouin, D.E. Fogg*, Adv. Synth. Catal. 2008, 350, 773-777.
"MALDI Mass Spectrometry as a Tool for Insight in Organotransition-Metal Catalysis." M.D. Eelman, J.M. Blacquiere, M.M. Moriarty, D.E. Fogg*, Angew. Chem. Int. Ed., 2008, 47, 303-306 (VIP Paper; featured on inside cover).
2007
"Tandem ROMP-Hydrogenation with a Third-Generation Grubbs Catalyst." K.D. Camm, N. Martinez Castro, Y. Liu, P. Czechura, D.E. Fogg*, J. Am. Chem. Soc., 2007, 129, 4168-4169.
"Oligomers as Intermediates in Ring-Closing Metathesis." Jay C. Conrad, Melanie D. Eelman, Jo‹o A. Duarte Silva, Sebastien Monfette, Henrietta H. Parnas, Jennifer L. Snelgrove, and Deryn E. Fogg*, J. Am. Chem. Soc., 2007, 129, 1024-1025.
"Transition Metal Catalysts in Organic Synthesis: Ring-Opening Metathesis Polymerization." D.E. Fogg*, H. Foucault, Comprehensive Organometallic Chemistry III, R.H. Crabtree, D.M.P. Mingos, Eds., Elsevier: Oxford 2007, Vol. 11, Ch. 6.3, pp. 623-652.
"From Drug Cocktails to Tissue Engineering: Synthesis of ROMP Polymers for Biological Applications." K.D. Camm, D.E. Fogg*, in Metathesis Chemistry: Nanostructure Design to Advanced Materials, NATO Adv. Chem. Series; Y. Imamoglu, V. Dragutan, Eds., 2007, p. 285-303.
"Ru-Aryloxide Catalysts for Olefin Metathesis." S. Monfette, J.C. Conrad, J.M. Blacquiere, N. Beach, D.E. Fogg*, in Metathesis Chemistry: Nanostructure Design to Advanced Materials, NATO Adv. Chem. Ser.; Y. Imamoglu, V. Dragutan, Eds., 2007, p. 79-89.
2006
"Saturated Neoglycopolymers as Collagen Cross-linking Agents." D.E. Fogg, Y. Liu, M. Griffith, US Patent App., US 11/442,755, filing date May 30, 2006.
"Tandem ROMP-Hydrogenation Catalysis." D.E. Fogg, K.D. Camm, U.S. Provisional Patent, 2006, US 60/824,345.
"A Chelate-Stabilized Ruthenium(σ-Pyrrolato) Complex." H.M. Foucault, D.L. Bryce*, D.E. Fogg*, Inorg. Chem. 2006, 45, 10293-10299.
"Mass Spectrometric Analysis of Organometallics: Ionization Mechanisms and the Probability of Survival." M.D. Eelman, M.M. Moriarty, D.E. Fogg*, Educ. Adv. Chem. (invited), 2006, 10, 213-234.
"Ruthenium Metathesis Catalysts containing Chelating Aryloxide Ligands." S. Monfette, D.E. Fogg*, Organometallics, 2006, 25, 1940-1944.
"Ru-Aryloxide Metathesis Catalysts with Enhanced Lability." J.C. Conrad, K.D. Camm, D.E. Fogg*, Inorg. Chim. Acta (invited; van Koten issue), 2006, 359, 1967-1973.
"Ruthenium-Catalyzed Ring-Closing Metathesis: Advances, Limitations, and Opportunities." J.C. Conrad, D.E. Fogg*, Curr. Org. Chem. (invited), 2006, 10, 185-202.
"Exploring the Electronic Structure of Ru Catalysts using X-ray Absorption." M.U. Delgado-Jaime, J.C. Conrad, D.E. Fogg, P. Kennepohl*, Inorg. Chim. Acta, invited (B.R. James issue), 2006, 359, 3042-3047.
"Gold(I) NHC Complexes Bearing Biologically Compatible Moieties." P. de Frémont, E.D. Stevens, M.D. Eelman, D.E. Fogg, S.P. Nolan*, Organometallics, 2006, 25, 5824-5828.
"Ru-Aryloxide Catalysts in Metathesis." J.C. Conrad, J.L. Snelgrove, M.D. Eeelman, S. Hall, D.E. Fogg*, J. Mol. Catal. A (olefin metathesis issue: invited), 2006, 254, 105-110.
2005
"Highly Efficient Ru-Pseudohalide Catalysts for Olefin Metathesis." J.C. Conrad, H.H. Parnas, J.L. Snelgrove, D.E. Fogg*, J. Am. Chem. Soc. 2005, 127,11882-11883.
"Simultaneous Observation of Doubly- and Triply-Chloride Bridged Isomers.Ó S.D. Drouin, S. Monfette, D. Amoroso, G.P.A. Yap, D.E. Fogg,* Organometallics, 2005, 24, 4721-4728.
"New Pseudohalide Ligands in Ru-Catalyzed Olefin Metathesis: A Robust, Air-Activated Iminopyrrolato Catalyst." S.D. Drouin, H. M. Foucault, G.P.A. Yap, D. E. Fogg*, Can. J. Chem. (special issue in honour of Howard Alper), 2005, 83, 748.
"N-Heterocyclic Carbenes as Activating Ligands in Hydrogenation and Isomerization of Unactivated Olefins." U. Dharmasena, H. M. Foucault, E.N. dos Santos, D.E. Fogg*, S. P. Nolan, Organometallics, 2005, 24,1056.
"Inhibiting s-p Isomerization of Aryloxide in Late Transition Metal Complexes." J.L. Snelgrove, J. Conrad, M. Eelman, M.M. Moriarty, G.P.A. Yap, D. E. Fogg*, Organometallics, 2005, 24, 103-109.
