Synthetic and Medicinal Organic Chemistry;
Natural Product Isolation and Bioassays
- Position: Professor
- Education: Ph.D. (Western Ontario)
- Phone: (613) 562-5800 ext 6072
- Fax: (613) 562-5170
- E-Mail: firstname.lastname@example.org
University of Ottawa Professor of the Year, 1999, for Excellence
Title of award lecture. Building Better Aspirins. From Willow
Bark to Enzyme Inhibitors.
- Synthesis of compounds of medicinal interest often using Diels-Alder
reactions involving o-quinodimethanes as a key step.
- Optically active à-amino acids via dynamic kinetic resolution
[DKR]. Synthesis of the ACE inhibitors, Enalapril and Benazapril, via
the DKR approach.
- Benzyne Chemistry. Synthesis of 2-substuted-iodobenzenes. The formation
of these products takes place via iodine ate complexes as intermediates.
Development of this reaction type as a route to a variety of substituted
benzenes. The preparation of benzocyclobutenonone and-cyclobutenols
via the reaction of benzynes and ketone and ester enolates
- Natural product chemistry (jointly with Professor J.T. Arnason,
Department of Biology). Topics in this area include (i) isolation and
characterization of plant metabolites as insect control agents; (ii)
antimalarials derived from extracts of plants native to Cosata Rica
and Indonesia; (iii) Evaluation of extracts from members of the Marcgraviaceae
family as natural anti-anxiety drugs; Chemical investigation of rare
plant species. Currently we are isolating products from a new member
of the Canelaceae family recently identified by our botanist colleagues,
Luis Poveda and and Pablo Sanchez , at the Universida Nacional Costa
- Design and Synthesis of anti-oxidants based on theoretical calculations
[Prof. Jim Wright., Carleton University]. Targets include modified versions
of Vitamin E, reveratrol [a natural cancer preventative islated from
red grapes], and other 1,2-dihydroxybenzenes. Preparation of
dendrityic anti oxidants.
- S. Tripathy, H.Hussain and Tony Durst. Iodine Ate Complexes and
N-Lithiobenzocyclobutenamine Intermediates in the reactions of alpha-Lithionitriles
with Benzynes. Submitted to tetrahedron Letters. May 2000.
- S.Tripathy, R. Leblanc and T. Durst. Conversion
of Iodobenzenes to 2-substituted iodobenzenes via benzyne intermediates.
Organic Letters, 1999, 1, 1973-1976.
- (126) R. N. Ben and Tony Durst. The synthesis of optically
active a-amino esters via dynamic kinetic resolution (DKR): A mechanistic
study. J. Org. Chem. 1999, 64, 7700-7706.
- A.-S. Belzile, S. L. Majerus, C. Podesfinski, G. Guillet, T. Durst
and J. T. Arnason. Dillapiol Derivatives as synergists. Structure-Activity
relationships. Pesticide Biol. Biochem. (1999). (Accepted)
- S.L. MacKinnon, C. Bensimon, J.T. Arnason, P.E. Vindas-Sanchez
and T. Durst. Spirocaracollitones CD-spirotriterpenoids from
Ruptiliocarpon Caracolito. J. Org. Chem.1997, 62, 840-845.
- S.L. MacKinnon, T. Durst, J.T. Arnason, C. Angerhofer, J. Pezzuto,
P.E. Sanchez- Vindas, L.J. Proveda, M. Gbeassor. Antimalerial
activity of tropical meliaceae extracts and gedunin derivatives.
J. Nat. Product 1997 60, 336-341
- T.J. Connolly and T. Durst. Photochemically generated bicyclic
o-quinodimethanes. Photoenolization of bicyclic aldehydes and
ketones.Tetrahedron. 1997, 53, 15969-15982.
- (119) T.J. Connolly and T. Durst. The synthesis of o-quinodimethanes
from tricyclic sulfones. Tetrahedron. 1997, 53, 15957-15968.