RECENT JOURNAL PUBLICATIONS

  1. Michael Santos Souweha, Akram Arab, Megan ApSimon, Alex G. Fallis. Diene-Transmissive Cycloadditions: Control of Monocycloaddition by Self-Assembly on a Lewis Acid Template, Org. Lett. , 9, 615-618, (2007). DOI

  2. Matthew D. Clay and Alex G. Fallis. Acetylenic Allenophanes: An Asymmetric Synthesis of a bis-Alleno-bis-butadiynyl-meta-cyclophane, Angew. Chem. Int. Ed. 44, (26) 4039-4042, (2005). PDF

  3. Matthew D. Clay, Ditte Riber and Alex G. Fallis. Competing Diels-Alder Intramolecular Pathways from Cross Conjugated Trienes: Fused Hydrindenones (Bicyclo[4.3.0]nonenones) versus Bridged Ring (Bicyclo[3.3.1]nonenones) Adducts from a Diene-Transmissive Precursor, Can. J. Chem. 83, (6-7) 559-568, (2005). PDF

  4. David V. Smil, Fabio E. Souza, Alex G. Fallis. A general carbometalation, three component coupling strategy for the synthesis of a,b-unsaturated g-sultines including thio-rofecoxib, a selective COX-2 inhibitor, Bioorg. Med. Chem. Lett. 15, (8) 2057-2060, (2005). PDF

  5. Pierre E. Tesser, Natalie Nguyen, Matthew D. Clay and Alex G. Fallis. Aryl Annulation of Cyclic Ketones via a Magnesium Carbometalation-6-pi Electrocyclization Protocol, Org. Lett. 7, (5) 767-770, (2005). PDF  

  6. Alain Laurent, Nidia P. Villava-Serin, Pat Forgione, Peter D. Wilson, David V. Smil and Alex G. Fallis. Part 1: Efficient strategies for the construction of variably substituted bicyclo[5.3.1]-undecenones (AB taxane ring systems), Can. J. Chem. 82, (2) 215-226, (2004). PDF

  7. Alex G. Fallis. Adventures with acetylenes: A personal odyssey from wyerone and crepenynic acid to enediynes, acetylenic cyclophanes, and propargyl alcohols, Synlett 13, 2249-2267, (2004). PDF

  8. Nidia P. Villava-Serin, Alain Laurent and Alex G. Fallis. Efficient strategies for the construction of variably substituted bicyclo[5.3.1]undecenones (AB-taxane ring systems) and their conversion to tricyclo[9.3.1.03,8]pentadecenones (ABC taxane ring systems) and bicyclo[2.2.2]octanones, Can. J. Chem. 82, (2) 227-239, (2004). PDF  

  9. Pierre E. Tessier, Andrea J. Penwell, Fabio E.S. Souza, and A.G. Fallis. (Z)-Tamoxifen and Tetrasubstituted Alkenes and Dienes via a Regio- and Stereospecific Magnesium Carbometallation Palladium(0) Cross-Coupling Strategy, Org. Lett. 5, (17) 2989-2992, (2003). PDF  

  10. N.P. Villava-Serin, A. Melekov, and A.G. Fallis. Indium(I) Mediated, Tandem Carbonyl Addition-oxy-Cope Rearrangement of gamma-Pentadienyl Anions to Cyclohexenones and Conjugated Aromatic Ketones, Synthesis (5), 790-794, (2003) PDF  

  11. Matthew A. Heuft, Shawn K. Collins, and Alex G. Fallis. Molecular Folding of C60 Acetylenic Cyclophanes: pi-Stacking of Superimposed Aromatic Rings, Org. Lett. 5, (11) 1911-1914, (2003). PDF  

  12. N.P. Villava-Serin, Alain Laurent, Glenn P.A. Yap, and A.G. Fallis. A Direct Carbometallation-Stereoselective Cycloaddition-Ring Closing Metathesis Route to the Tricyclic ABC Core of Taxoids, Synlett (9), 1263-1264 (2003). PDF  

  13. D.V. Smil, A. Laurent, N.S. Spassova, and A.G. Fallis. A Stereoselective Intramolecular Diels-Alder Strategy for the Tricyclo[9.3.1.03,8]-pentadecane Core of Aromatic C-Ring Taxanes, Tetrahedron Lett. 44, (27) 5129-5132, (2003). PDF  

  14. M.A. Heuft and A.G. Fallis. Template-Directed Synthesis of Helical Phenanthroline Cyclophanes, Angew. Chem. Int. Ed. 41, (23) 4520-2523, (2002). PDF  

  15. S.K. Collins, G.P.A. Yap, and A.G. Fallis. A Novel Strained Undecadiyne Cyclophane with Interesting Dienophilic Character, Org. Lett. 4, (1) 11-14, (2002). PDF  

  16. M.A. Heuft, S.K. Collins, G.P.A. Yap, and A.G. Fallis. Synthesis of Diynes and Tetraynes from in situ Desilylation/Dimerization of Acetylenes, Org. Lett. 3, (18) 2883-2886, (2001). PDF  

  17. B.M. Comanita, M.A. Heuft, T. Rietveld, and A.G. Fallis. A Mild Route to -Alkoxyacetylenes Mediated by Lewis Acids and Synthetic Routes to 10, 11, and 12 Membered Ring Enediyne Carbocycles, Israel J. Chem. 40, (3-4) 241-253, (2001).

  18. C. Martin, N. Mackintosh, N. Lamb, and A.G. Fallis. Benzobicyclo[8.4.0.0]tetradecenones: Ring CD-Taxoid Models by Planar Tether Controlled Cycloaddition, Org. Lett. 3, (7) 1021-1023, (2001). PDF  

  19. A.G. Fallis and P. Forgione, Metal Mediated Carbometallation of Alkynes and Alkenes Containing Adjacent Heteroatoms, Tetrahedron 57, 5899-5913, (2001).

  20. S.K. Collins, G.P.A. Yap, and A.G. Fallis. Synthesis of Novel Acetylenic Cyclophanes with Helical Chirality: Potential New Structures for Liquid Crystals, Org. Lett. 2, (20) 3185-3187, (2000). PDF  

  21. A. Melekov, P. Forgione, S. Legoupy, and A.G. Fallis. Tether-Controlled Cycloadditions for the Asymmetric Synthesis of Decalins: Increased Selectivity in Acetonitrile Solvent, Org. Lett. 2, (18) 2793-2796, (2000). PDF  

  22. P. Forgione, P.D. Wilson, G.P.A. Yap, and A.G. Fallis. A Carbometallation-Intramoecular Cycloaddition Strategy for the AB-Taxane Ring and an Enone Accelerated Cope Rearrangement to Bicyclo[2.2.2]octanones, Synthesis (7), 921-924, (2000).

  23. A.G. Fallis. P. Forgione, S. Woo, S. Legoupy, S. Py, C. Harwig, and T. Rietveld, Organometallic Reagents and Protocols for Synthesis, Polyhedron 19, (5), 533-535, (2000).

  24. S.K. Collins, G.P.A. Yap, and A.G. Fallis. The Synthesis of a Novel Strained Diyneparacyclophane and its Dimer by Metal Mediated Coupling, Angew. Int. Ed. Engl. 39, (2) 385-388, (2000). PDF  

  25. P. Forgione, P.D. Wilson, and A.G. Fallis. Magnesium Mediated Carbometallation of Propargyl Alcohols: Direct Routes to Furans and Furanones, Tetrahedron Lett. 41, (1) 17-20, (2000). PDF  

  26. P. Forgione and A.G. Fallis. Magnesium Mediated Carbometallation of Propargyl Alcohols: Direct Routes to Dihydroxydienes and Enediyne Alcohols Tetrahedron Lett. 41, (1) 11-16, (2000).         PDF  

  27. A.G. Melekov and A.G. Fallis. Indium Mediated -Pentadienylation of Conjugated Aldehydes: Synthons for Hydrindanes by an Oxy-Cope-Cycloaddition Strategy, Tetrahedron Lett. 40, (45) 7867-7870, (1999).

  28. S. Woo, S. Legoupy, S. Parra, and A.G. Fallis. A Diene Transmissive Diels-Alder Strategy for Oxygenated Nor-Steroid and Triterpenoid Skeletons, Org. Lett. 1, (7) 1013-1016, (1999).

  29. S. Woo, N. Squires, and A.G. Fallis. Indium Mediated -Pentadienylation of Aldehydes and Ketones: Cross-Conjugated Trienes for Diene-Transmissive Cycloadditions , Org. Lett. 1, (4) 573-575, (1999).

  30. B.M. Comanita and A.G. Fallis. A Versatile Tandem Retro-[1,4]-Brook Rearrangement-Condensation Reaction of O-Bromoacetophenone Silyl Enol Ethers, Tetrahedron Lett. 40, (26), 5283-5289, (1999).

  31. P. Tauh and A.G. Fallis. Rate Constants for 5-Exo Secondary Alkyl Radical Cyclizations onto Hydrazones and Oxime Ethers, J. Org. Chem., 64, (19) 6960-6968, (1999).

  32. A.G. Fallis. Tangents and Targets: The Synthetic Highway from Natural Products to Medicine, Can. J. Chem. 77, (2) 159-177 (1999).

  33. A.G. Fallis. Harvesting Diels and Alder's Garden, Acc. Chem. Research, 32, (6), 464-474, (1999).

  34. S. Py, C.W. Harwig, S. Banerjee, D.L. Brown, and A.G. Fallis. Taxamycin Studies: A Bicylo[7.3.1]trideca-4,9-dien-2,6-diyne, Calicheamicin Type Analog, Tetrahedron Lett. 39, (34), 6139-6142, (1998).

  35. M. Dimitroff and A.G. Fallis. Studies of -Diastereofacial Selectivity: Spiro 2-Tetrahydrofuran and 2-Tetrahydrothiophene Ketones,Tetrahedron Lett. 39, (17), 2531-2534, (1998).

  36. M. Dimitroff and A.G. Fallis. Studies of -Diastereofacial Selectivity: The Influence of -Oxathiolane Ketals on Cyclic Ketones, Tetrahedron Lett. 39, (17), 2527-2530, (1998).

  37. A.G. Fallis and I. Brinza, Free Radical Cyclizations Involving Nitrogen, Tetrahedron 53, (52) 17543-17594, (1997).

  38. C.W. Harwig, S. Py, and A.G. Fallis. Taxamycin Studies: CrCl2/NiCl2 Mediated Cyclizations and Unusual SeO2 Oxidations, J. Org. Chem., 62, (23) 7902-7903, (1997).

  39. T.Wong, P.D. Wilson, S. Woo, and A.G. Fallis. Isopropylidene Acetals: Chiral Tether Control Groups for Asymmetric Intramolecular Diels-Alder Reactions, Tetrahedron Lett. 38, (40) 7045-7048, (1997).

  40. M.W. Tjepkema, T. Wong, P.D. Wilson, and A.G. Fallis. Functionalization and Elaboration of Ring A Taxoid Building Blocks, Can. J. Chem. 75, (11) 1542-1551, (1997).

  41. M.W. Tjepkema, P.D. Wilson, H. Audrain, and A.G. Fallis. Ring A Building Blocks for Taxoids and Taxamycins Can. J. Chem. 75, (9) 1215-1224, (1997).

  42. S. Banerjee, A.G. Fallis. and D.L. Brown, Differential Effects of Taxol on Two Human Cancer Cell Lines, Oncology Res. 9, 237-248, (1997).

  43. S. Millan, T.T. Pham, J.A. Lavers, and A.G. Fallis. Planar Tether Control Groups and -Facial Selectivity: Intramolecular Cycloadditions for Polycyclic Systems, Tetrahedron Lett. 38, (5) 795-798, (1997).

  44. A.G. Fallis. From Tartrates to Taxoids: A Double Intramolecular Diels-Alder Strategy, Pure Appl. Chem. 69, (3) 495-500 (1997).

 

Recent Conference Proceedings and Student Presentations

  1. M. D. Clay and A.G. Fallis. A Tether Controlled Intramolecular Diels-Alder Approach to Hydrindanes, Ont./Que. Minisymposium in Synthetic/Bioorganic Chemistry, Kingston, Ont., November 9-11, 2002.

  2. E. Husk and A.G. Fallis. The Role of Dienes in the Synthesis of Taxoids, Ont./Que. Minisymposium in Synthetic/Bioorganic Chemistry, Kingston, Ont., November 9-11, 2002.

  3. P. Tessier and A.G. Fallis. Multi-component Coupling: Novel Ring Annulations via a Carbometallation Strategy, Ont./Que. Minisymposium in Synthetic/Bioorganic Chemistry, Kingston, Ont., November 9-11, 2002.

  4. M. A Heuft and A.G. Fallis. Molecular Folding of C60 Acetylenic Cyclophanes, Ont./Que. Minisymposium in Synthetic/Bioorganic Chemistry, Kingston, Ont., November 9-11, 2002.

  5. N.P. Villalva and A.G. Fallis. A Carbometallation-CycloadditionpRCM Approach to the ABC Taxoid Ring System, 85th Canadian Chemical Conference of the C.S.C., Vancouver, BC, June 1-5, 2002

  6. M.A. Heuft, J. Tiffin, P. Tessier, and A.G. Fallis Acetylenic Cyclophanes, 85th Canadian Chemical Conference of the C.S.C., Vancouver, BC, June 1-5, 2002.

  7. S. K. Collins and A.G. Fallis. Synthesis of Novel C60 Acetyleneic Cyclophanes, 84th Canadian Chemical Conference of the C.S.C., Montreal, Quebec, May 27-31, 2001.

  8. M. A. Heuft and A.G. Fallis. Synthesis of Novel Phenanthrolenic Cyclophanes, 84th Canadian Chemical Conference of the C.S.C., Montreal, Quebec, May 27-31, 2001.

  9. S. K. Collins and A.G. Fallis. Novel Acetylenic Cyclophanes with Helical Chirality as Potential New Structures for Liquid Crystals, 84th Canadian Chemical Conference of the C.S.C., Montreal, Quebec, May 27-31, 2001.

  10. S.K. Collins and A.G. Fallis. Synthesis of Novel C60 Acetyleneic Cyclophanes, 84th Canadian Chemical Conference of the C.S.C., Montreal, Quebec, May 27-31, 2001.

  11. M. A Heuft and A.G. Fallis. Synthesis of Helical Acetylenic Cyclophanes, Ont./Que. Minisymposium in Synthetic/Bioorganic Chemistry, Toronto, Ont., November 9-11, 2000.

  12. S. Collins and A.G. Fallis. Novel C60 Acetylene Cyclophanes, Ont./Que. Minisymposium in Synthetic/Bioorganic Chemistry, Toronto, Ont., November 9-11, 2000.

  13. P. Forgione, P.D. Wilson, A. Laurent, and A.G. Fallis. Carbometallation of Propargyl Alcohols: A Route to Furans and Decalins, Organic Synthesis Symposium, 83rd Canadian Chemical Conference of the C.S.C., Calgary, AB, May 28-31, 2000.

  14. S.M. Parra, M.L. Lee, and A.G. Fallis. A Double Diels-Alder Strategy Towards Taxoids, 83rd Canadian Chemical Conference of the C.S.C., Calgary, AB, May 28-31, 2000.

  15. A.G. Melekhov, S. Legoupy, P. Forgione, M.-L. Lee, and A.G. Fallis. The Advantage of cis-Isopropylidene Acetals as Tether Control groups for the Asymmetric Synthesis of Decalins, Abstract ORGN 546, 218th, National Meeting of the American Chemical Society, New Orleans, LA, U.S.A., Auhust 22-26, 1999.

  16. C. Martin, N. Mackintosh, P.Forgione, S. Woo, S. Legoupy, M.L. Lee, and A.G. Fallis. Organometallic Mediated Routes to Dienes 10th International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis, Vesailles, France, July 18-22, 1999.

  17. A.G. Fallis. P.Forgione, S. Woo, S. Legoupy, S. Py, C. Harwig, and T. Rietveld, Organometallic Reagents and Protocols for Synthesis, 10th International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis, Vesailles, France, July 18-22, 1999.

  18. A.G. Fallis. S. Woo, S. Legoupy, M.-L Lee, and T. Rietveld, Synthetic Studies Directed Towards Taxoid Analogues for Breast Cancer, Breast Cancer Research: Reasons for Hope, Toronto, Ontario, June17-19, 1999.

  19. P. Forgione and A.G. Fallis. Carbometallation of Propargyl Alcohols: A Route to Furans and Decalins, Organic Synthesis Symposium, 82nd Canadian Chemical Conference of the C.S.C., Toronro, Ont., May 31-June 5, 1999.

  20. T. Rietveld and A.G. Fallis. Antiestrogen-Enediyne Antitumor Agents: Synthetic Studies, Ottawa Life Sciences Council Meeting, 82nd Canadian Chemical Conference of the C.S.C., Toronro, Ont., May 31-June 5, 1999.

  21. S. Collins and A.G. Fallis. Synthesis of Novel Acetylenic Cyclophanes with Helical Chirality, 82nd Canadian Chemical Conference of the C.S.C., Toronro, Ont., May 31-June 5, 1999.

  22. S. Parra and A.G. Fallis. A Sequential Cycloaddition Approach to Taxoids, 82nd Canadian Chemical Conference of the C.S.C., Toronto, Ont., May 31-June 5, 1999.

  23. S. Collins and A.G. Fallis. Synthesis of Novel Acetylenic Cyclophanes with Helical Chirality, Organic Synthesis Symposium, University of Montreal, Montreal, Quebec, April 15-16, 1999.

  24. P. Forgione and A.G. Fallis. A Convenient Route to Furans and Decalins, Organic Synthesis Symposium, University of Montreal, Montreal, Quebec, April 15-16, 1999.