44. Lemay, M.; Trant, J. and Ogilvie, W.W. “Hydrazide-catalyzed 1,3-dipolar nitrone cycloadditions”, Tetrahedron, 2007, 63, 11644-11655.
43. Flynn, A.B. and Ogilvie, W.W. “Stereocontrolled Synthesis of Tetrasubstituted Olefins” Chemical Reviews, 2007, 107, 4698-4745.
42. Goudreau, N.; Cameron, D.R.; Déziel, R.; Haché, B.; Jakaliana, A.; Malenfant, E.; Naud, J.; Ogilvie, W.W.; O’Meara, J.; White, P.W.; Yoakim, C. “Optimization and determination of the absolute configuration of a series of potent inhibitors of human papillomavirus type-11 E1–E2 protein–protein interaction: A combined medicinal chemistry, NMR and computational chemistry approach” Bioorganic & Medicinal Chemisty, 2007, 2690-2700.
41. Ho, M.N.; Lemay, A.B.; and Ogilvie, W.W. “Single Isomer Iodochlorination of Alkynes and Chlorination of Alkenes Using Tetrabutylammonium Iodide and Dichloroethane” Journal of Organic Chemistry, 2007, 72, 977-983.
40. Lemay, M., Aumand, L. and Ogilvie, W.W. “Design of a Conformationally Rigid Hydrazide Organic Catalyst”, Advanced Synthesis and Catalysis, 2007, 349, 441-447.
39. Lemay, M. and Ogilvie, W.W. “Mechanistic Studies of Hydrazide Catalyzed Enantioselective Diels-Alder Reactions”, Journal of Organic Chemistry, 2006, 71, 4663-4666.
38. Lemay, A.B.; Vulic, K.S.; and Ogilvie, W.W. “Single Isomer Tetrasubstituted Olefins from Regioselective and Stereospecific Palladium-Catalyzed Coupling of -Chloro--Iodo--Unsaturated Esters” Journal of Organic Chemistry, 2006, 71, 3615-3618.
37. Lemay, M. and Ogilvie, W.W. “Aqueous Enantioselective Organocatalytic Diels-Alder Reactions Employing Hydrazide Catalysts. A new Scaffold for Organic Acceleration.” Organic Letters, 2005, 7, 4141-4144.
36. O’Meara, J.A.; Yoakim, C; Bonneau, P.R.; Bös, M.; Cordingley, M.G.; Déziel, R.; Doyon, L.; Duan, J.; Garneau, M.; Guse, I.; Landry, S.; Malenfant, E.; Naud, J.; Ogilvie, W.W; Thavonekham, B.; Simoneau, B. Journal of Medicinal Chemistry, 2005, 48, 5580-5588
35. Charbonneau, V. and Ogilvie, W.W. “High Throughput Screening Methods for Asymmetric Synthesis”, Mini-Reviews in Organic Chemistry.
34. Yoakim, C.; Bonneau, P.R; Déziel, R.; Doyon, L.; Duan, J.; Guse, I.; Landry, S.; Malenfant, E.; Naud, J.; Ogilvie, W.W.; O’Meara, J.A.; Plante, R.; Simoneau, B.; Thavonekham, B.; Bös, M.; Cordingley, M. “Novel nevirapine-like inhibitors with improved activity against NNRTI-resistant HIV: 8-heteroarylthiomethyl-dipyridodiazepinone derivatives” Bioorganic & Medicinal Chemistry Letters, 2004, 14, 739-742
33. Davidson, W.; McGibbon, G. A.; White, P. W.; Yoakim, C.; Hopkins, J. L.; Guse, I.; Hambly, D. M.; Frego, L.; Ogilvie, W.W.; Lavallee, P.; Archambault, J. “Characterization of the Binding Site for Inhibitors of the HPV11 E1-E2 Protein Interaction on the E2 Transactivation Domain by Photoaffinity Labeling and Mass Spectrometry”, Analytical Chemistry, 2004, 76, 2095-2102.
32. Beaulieu, P.; Ogilvie, W.W. “A sequential Claisen/ring closing metathesis approach to the synthesis of spirocyclic cyclopentanes and cyclohexanes” Tetrahedron Letters, 2003, 44, 8883-8885.
31. Yoakim, C.; Goudreau, N.; McGibbon, G.A.; O’Meara, J.; White, P.W.; Ogilvie, W.W. “Structure Elucidation of the First Inhibitors of Human Papillomavirus Type 11 E1-E2 Protein-Protein Interaction.” Helvetica Chimica Acta, 2003, 86, 3427-3444.
30. Yoakim, C.; Ogilvie, W.W.; Goudreau, N.; Naud, J.; Haché, B.; O’Meara, J.A.; Cordingley, M.G.; Archambault, J.; White, P. “Discovery of the First Series of Inhibitors of Human Papillomavirus Type 11: Inhibition of the Assembly of the E1–E2–Origin DNA Complex”, Bioorganic & Medicinal Chemistry Letters, 2003, 13, 2539-2541.
29. White, P.W.; Titolo, S.; Brault, K.; Thauvette, L.; Pelletier, A.; Welchner, E.; Bourgon, L.; Doyon, L.; Ogilvie, W.W.; Yoakim, C.; Cordingley, M.G.; Archambault, J. “Inhibition of human papillomavirus DNA replication by small molecule antagonists of the E1-E2 protein interaction” Journal of Biological Chemistry, 2003, 278, 26765-26772.
28. Guindon, Y.; Ogilvie, W.W.; Bordeleau, J.; Cui, W.L.; Durkin, K.; Gorys, V.; Juteau, H. Lemieux, R.; Liotta, D.; Simoneau, B.; Yoakim, C. “Opening of Tartrate Acetals Using Dialkylboron Bromide. Evidence for Stereoselectivity Downstream from Ring Fission.” Journal of the American Chemical Society, 2003, 125, 428-436.
27. Ogilvie, W.W. "Non-Nucleoside Inhibitors of the Human Cytomegalovirus" Current Medicinal Chemistry – Anti-Infective Agents, 2002, 1, 177-191.
26. Guindon, Y.; Soucy, F.; Yoakim, C.; Ogilvie, W.W.; Plamondon, L. "Diastereoselective Synthesis of 2,3,5-trisubstituted Tetrahydrofurans via Cyclofunctionalization Reactions." Journal of Organic Chemistry, 2001, 66, 8992-8996.
25. Simoneau, B.; Pavallée, P.; Bailey, M.; Duceppe, J.-S.; Grand-Maître, C.; Grenier, L.; Ogilvie, W.W.; Poupart, M.-A.; Thavonekham, B. “Stereoselective Synthesis of Renin Inhibitor BILA 2157 BS.” Canadian Journal of Chemistry, 2000, 739-748.
24. Guérin, B.; Chabot, C.; Mackintosh, N.; Ogilvie, W.; Guindon, Y. “Free Radicals and Lewis Acid. Chelation-Controlled Radical Allylations of Substituted a-Halo- or a-Phenylseleno-b-Alkoxy Esters. The Endocyclic Effect.” Canadian Journal of Chemistry, 2000, 852-867
23. Bonneau, P.R.; Hasani, F.; Plouffe, C.; Malenfant, E.; LaPlante, S.R.; Guse, I.; Ogilvie, W.W.; Plante, R.; Davidson, W.C.; Hopkins, J.L.; Morelock, M.M.; Cordingley, M.G.; Déziel, R. “Inhibition of Human Cytomegalovirus Protease by Monocyclic b-Lactam Derivatives: Kinetic Characterization Using a Fluorescent Probe” Journal of the American Chemical Society, 1999, 121, 2965-2973.
22. Ogilvie, W. W.; Yoakim, C.; Dô, F.; Haché, B.; Lagacé, L.; Naud, J.; O’Meara, J.A.; Déziel, R. “Synthesis and Antiviral Activity of Monobactams Inhibiting the Human Cytomegalovirus Protease” Bioorganic & Medicinal Chemistry, 1999, 7, 1521-1531.
21. Nicolaou, K.C.; Shi, G.-O.; Gunzer, J.L.; Gartner, P.; Wallace, P.A.; Ouellette, M.A.; Shi, S.; Bunnage, M.E.; Agrios, K.; Veale, C.A.; Hwang, C.-K.; Hutchinson, J.; Prasad, C.V.C.; Ogilvie, W.W.; Yang, Z. “Total Synthesis of Brevetoxin A: Part 3: Construction of GHIJ and BCDE ring systems.” Chem. Eur. J. 1998, 5, 628-645.
20. Simoneau, B.; Lavallée, P.; Anderson, P.C.; Bailey, M.; Bantle, G.; Berthiaume, S.; Chabot, C.; Fazal, G.; Halmos, T.; Ogilvie, W.W.; Poupart, M.-A.; Thavonekham, B.; Xin, Z.; Thibeault, D.; Bolger, G.; Panzenbeck, M.; Winquist, R.; Jung, G.L. “Discovery of Non-Peptidic P2-P3 Butanediamide Renin Inhibitors with High Oral Efficacy” Bioorganic & Medicinal Chemistry, 1998, 7, 489-508.
19. LaPlante, S. R.; Cameron, D. R.; Aubry, N.; Bonneau, P. R.; Déziel, R.; Grand-Maître, C.; Ogilvie, W. W.; Kawai, S. H. “The Bound Conformation of a Peptidyl Methyl Ketone Inhibitor of the Human Cytomegalovirus Protease” Angewandte Chemie. International Edition in English. 1998, 37, 2729-2732.
18. Yoakim, C.; Ogilvie, W. W.; Cameron, D. R.; Chabot, C.; Grand-Maître, C.; Guse, I.; Haché, B.; Kawai, S.; Naud, J.; O’Meara, J. A.; Plante, R.; Déziel, R. “Potent b-Lactam Inhibitors of Human Cytomegalovirus Protease”, Antiviral Chemistry and Chemotherapy, 1998, 9, 379-387.
17. Yoakim, C.; Ogilvie, W. W.; Cameron, D. R.; Chabot, C.; Guse, I.; Haché, B.; Naud, J.; O’Meara, J. A.; Plante, R.; Déziel, R. “b-Lactam Derivatives As Inhibitors Of Human Cytomegalovirus Protease”, Journal of Medicinal Chemistry, 1998, 41, 2882-2891.
16. Guindon, Y.; Jung, G.; Guérin B.; Ogilvie, W.W. “Hydrogen and Allylation Transfer Reactions in Acyclic Free Radicals”, Synlett, 1998, 213-220.
15. Bonneau, P. ; Grand-Maître, C.; Greenwood, D.; Lagacé L.; LaPlante, S.; Massariol, M.-J.; Ogilvie, W.; O’Meara, J.; Kawai, S. “Evidence of a Conformational Change in the Human Cytomegalovirus Protease upon Binding of Peptidyl Activated Carbonyl Inhibitors”, Biochemistry, 1997, 36, 12644-12652.
14. Ogilvie, W.; Bailey, M.; Poupart, M.-A.; Abraham, A.; Bhavsar, A.; Bonneau, P.; Bordeleau, J.; Bousquet, Y.; Chabot, C.; Duceppe, J.-S.; Fazal, G.; Goulet, S.; Grand-Maître, C.; Guse, I.; Halmos, T.; Lavallée, P.; Leach, M.; Malenfant, E.; O'Meara, J.; Plante, R.; Plouffe, C.; Poirier, M.; Soucy, F.; Yoakim, C.; Déziel. R. “Peptidomimetic Inhibitors of the Human Cytomegalovirus Protease”, Journal of Medicinal Chemistry, 1997, 40, 4113-4135.
13. Guindon, Y.; Guérin, B.; Chabot, C.; Ogilvie, W. “Stereoselective Radical Carbon-Carbon Bond Forming Reactions of b-Alkoxy Esters: Atom and Group Transfer Allylations under Bidentate Chelation Controlled Conditions.” Journal of the American Chemical Society, 1996, 118, 12528-12535.
12. Guindon, Y.; Guérin, B.; Rancourt, J.; Chabot, C.; Mackintosh, N.; Ogilvie, W.W. "Lewis Acids in Diastereoselective Processes Involving Acyclic Radicals." Pure and Applied Chemistry, 1996, 68, 89-96.
11. Guindon, Y.; Guérin, B.; Chabot, C.; Mackintosh, N.; Ogilvie, W.W. "Stereoselective Radical Allylations of a-Iodo-b-Alkoxy Esters: Reversal of Facial Selectivity by Lewis Acid Complexation." Synlett, 1995, 449-451.
10. Guindon, Y.; Yoakim, C.; Gorys, V.; Ogilvie, W.W.; Delorme, D.; Renaud, J.; Robinson, G.; Lavallée, J. -F.; Slassi, A.; Jung, G.; Rancourt, J.; Durkin, K.; Liotta, D. "Stereoselective Hydrogen Transfer Reactions Involving Acyclic Radicals. Tandem Substituted Tetrahydrofuran Formation and Stereoselective Reduction: Synthesis of the C17-C22 Subunit of Ionomycin." Journal of Organic Chemistry, 1994, 59, 1166-1178.
9. Drouin, M.; Michel, A.G.; Guindon, Y.; Ogilvie, W. "Dimethyl (2R, 3R)-2-((Diphenylboro)oxy)-3-(((1S)-1cyclohexyl-1-bromomethyl)oxy)-1,4-butanedioate." Acta Crystallographica, Section C, 1993, C49, 75-77.
8. Guindon, Y.; Simoneau, B.; Yoakim, C.; Gorys, V.; Lemieux, R.; Ogilvie, W. "Stereoselective Opening of Acetals Derived from Dimethyl Tartrate", Tetrahedron Letters, 1991, 32, 5453-5456.
7. Nicolaou, K.C.; Veale, C.A.; Hwang, C.-K.; Hutchinson, J.; Prasad, C.V.C.; Ogilvie, W.W. "Novel Strategies for the Construction of Complex Polycyclic Ether Frameworks. Stereocontrolled Synthesis of the FGHIJ Ring System of Brevetoxin A", Angewandte Chemie. International Edition in English, 1991, 30, 299-303.
6. Nicolaou, K.C.; Ogilvie, W.W. "The Total synthesis of Amphoteronolide B and Amphotericin B", Chemtracts, 1990, 327-349.
5. Nicolaou, K.C.; Prasad, C.V.C.; Ogilvie, W.W. "Novel Stereocontrolled Synthesis of the Nonacene Ring System of Brevetoxin A. Conformational-Reactivity Effects in Nine-Membered Rings", Journal of the American Chemical Society, 1990, 112, 4988-4989.
4. Nicolaou, K.C.; McGarry, D.G.; Sommers, P.K.; Kim, B.H.; Ogilvie, W.W.; Yiannikouros, G.; Prasad, C.V.; Veale, C.A.; Hark, R.R. "Synthesis of Medium Sized Ring Ethers from Thionolactones. Application to Polyether Synthesis", Journal of the American Chemical Society, 1990, 112, 6263-6276.
3. Breau, L.; Ogilvie, W.W.; Durst, T. "Preparation of Optically Active Stillbene Oxides via Sulfonium Salts Derived from C2 Symmetric Thiolanes", Tetrahedron Letters, 1990, 35-38.
2. Ogilvie, W.W.; Durst, T. "Oxidation of 3-alkylidene-b-lactams. A preparation of 3-alkenyl-3-hydroxy-b-lactams", Canadian Journal of Chemistry, 1988, 66, 304-309.
1. Ogilvie, W.W.; Rank, W. "Thermolysis of geminal diazides: A novel route to 1,3,4-oxadiazoles", Canadian Journal of Chemistry, 1987, 65 166-169.
11. Yoakim C.; Hache B.; Ogilvie W. W.; O'meara J.; White P.; Goudreau N. “New indane derivative useful for preventing transmission of human papilloma virus from mother to baby”, US6759409 (2004)
10. R. Déziel, J. O'Meara, W. Ogilvie, B. Simoneau, C. Yoakim “Preparation of 9H-imidazo[1,2-d]dipyrido[2,3-b:3',2'-f][1,4]diazepine derivatives as tetracyclic non-nucleoside reverse transcriptase inhibitors useful against wild type and double-mutation K103N/Y181C enzymes”, International Patent WO 04026875 (2004).
9. R. Déziel, J. O'Meara, W. Ogilvie, B. Simoneau, C. Yoakim “Dipyridodiazepinones as reverse transcriptase inhibitors”, International Patent WO 03080612 (2003).
8. R. Déziel, J. O'Meara, W. Ogilvie, B. Simoneau “Preparation of dipyridodiazepinones as reverse transcriptase inhibitors”, International Patent WO 03011862 (2003).
7. R. Déziel, E. Malenfant, W. Ogilvie, B. Thavonekham, C. Yoakim “Preparation of 5,11-dihydro-8-(2-hydroxyethyl)-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one derivatives as non-nucleoside reverse transcriptase inhibitors”, US 2004106791 (2003).
6. R. Déziel, J. Naud, J. O'Meara, W. Ogilvie “Preparation of dipyridodiazepinones as reverse transcriptase inhibitors”, International Patent WO 02076982 (2002).
5. C. Yoakim, B. Hache, W.W. Ogilvie, J. O'Meara, P. White, N. Goudreau “Preparation of spiroheterocycles for therapeutic use as papilloma virus inhibitors” WO 0250082 (2002).
4. R. Déziel, E. Malenfant, J. O'Meara, W. Ogilvie “Azetidinone Derivatives for the Treatment of HCMV Infections”, WO9918071, (1999).
3. C. Chabot, R. Déziel, S. Kawai, J. O'Meara, W. Ogilvie, C. Yoakim “Azetidinone Derivatives for the Treatment of HCMV Infections”, WO9918073, (1999).
2. R. Déziel, J. O'Meara, W. Ogilvie, C. Yoakim “Azetidinone Derivatives for the Treatment of HCMV Infections”, WO9918072, (1999).
1. M. Bailey, G. Fazal, P. Lavallée, W. Ogilvie and M.-A. Poupart; “Peptidomimetic Inhibitors of the Human Cytomegalovirus Protease”, US Patent 6,291,640 B1 (1998).
1. Guérin, B.; Ogilvie, W.; Guindon, Ylewis Acid-Mediated Diastereoselective Radical Reactions” Chapter in “Radicals in Organic Synthesis Volume 1”, Sibi, M.; Renaud, P. editors, Wiley-VCH.
Contacte
(613) 562-5800 poste 6071
Téléc : (613) 562-5170
wogilvie@uottawa.ca
