Publications
Career numbers:
• Papers in refereed journals (accepted): 163
• Book Chapters: 4
• Patents or Patents Pending: 13
• Major invited contribution and/or technical reports: 3
Current H-Index: 55
Current i10-Index (Manuscripts cited 10 or more times): 141
Manuscripts Cited 100 Or More Times: 39
Total Citations: 13,223
Journal Articles Submitted:
167. Semeniuchenko, V.; Ovens, J.; Braje, W. M.; Organ, M. G. Organometallics, 2021NaBHT generated from BHT and NaOtBu: crystallographic characterization and applications in Buchwald-Hartwig amination.
166. Mohammadzadeh, A.; Sharif, S.; Semeniuchenko, V.; Townsend, N.; Corbett, A. D.; Organ, M. G. J. Org. Chem. 2021 (Manuscript Number ID jo-2021-01289j) Lithium Aluminum Hydride in Flow: Overcoming Exotherms, Solids, and Gas Evolution En Route to Chemoselective Reductions.
165. Semeniuchenko, V.; Sepideh, S.; Day, J.; Chandrasoma, N.; Pietro, W.; Manthorpe, J.; Braje, W. M.; Organ, M. G. J. Org. Chem. 2021 (Manuscript Number ID jo-2021-01057u) (DiMeIHeptCl)Pd: A Low-Load Catalyst for Efficient, Solvent-Free Amination.
164. Workmana, S. D.; Day, J.; Farhaf, M. A.; Brown, E. D.; Organ, M. G.; C. J. Strynadkaa, N. C. J. J. Med. Chem. 2021. (Manuscript Number ID jm-2021-00941r) Antimicrobial Agent and Chemotherapy Structural insight into the inhibition of undecaprenyl pyrophosphate 1 synthase from Gram-positive bacteria.
Journal Articles Accepted:
163. Semeniuchenko, V.; Braje, W. M.; Organ, M. G. Chem. Eur. J. 2021. In Press. (Manuscript Number ID chem.202101617) Sodium Butylated Hydroxytoluene (NaBHT): An Ideal Base for Solvent-Free, Pd-Catalysed Amination.
162. Morin, M. A.; Mallik, D.; Zhang, Organ, M. G. Angew. Chem. 2021, In Press. (Manuscript Number ID 202102009) Sampling and Analysis in Flow: The Keys to Smarter, More Controllable, and Sustainable Fine-Chemical Manufacturing.(https://doi.org/10.1002/anie.202102009)
161. Kwak, J. S.; Zhang, W.; Mallik, D.; Organ, M. G. Anal. Chem. 2021, In Press. (Manuscript Number ja-2020-09648q). Chiral API Development Redefined: Intelligent Multidimensional Purity Analysis and Confirmation Tool for Multiple Attribute Analysis.(https://doi.org/10.1021/acs.analchem.0c04652)
160. Morin, M. A.; Mallik, D.; Zhang, W.; Pietro, W.; Manthorpe, J. M.; Organ, M. G. Chem. Methods. 2021, ASAP (Manuscript Number ID chem.202004960). Obtaining Kinetics From Continuous Chemical Processes: Converting Space Into Time With the Switch of a Valve.(https://doi.org/10.1002/cmtd.202100003)
Spotlight Article
159. Nnamdi, F. U.; Diner, C.; Champagne, P. A.; Organ, M. G. Chem. Eur. J. 2021, 26, 3855- 3860. Experimental and Computational Study on the Anti-Markovnikov Hydrofunctionalization of Olefins Using Glycine-Extended AQ-Auxiliaries. (https://doi.org/10.1002/chem.202004881)
158. Eckert. P.; Sharif, S.; Organ, M. G. Angew. Chem. Int. Ed. 2021, 60, 12224-12241 (Angew. Chem. 2021, 133, 12332-12349). Salt to Taste: The Critical Roles Played by Inorganic Salts in Organozinc Formation and in the Negishi Reaction. (https://doi.org/10.1002/anie.202010917)
157. Kwak, J. S.; Bizarri, N.; Sharif, S.; Zhang, W.; Mallik, D.; Organ, M. G. Chem. Eur. J. 2020, 26, 15505-15508 The synthesis of warfarin using a reconfigurable-reactor platform integrated to a multiple variable optimization tool.(https://doi.org/10.1002/chem.202003700)
156. Eckert. P.; Organ, M. G. Chem. Eur. J. 2020, 26, 4861-4865. The critical role of LiBr in avoiding catalyst death of Pd-NHC complexes and its impact on cross-coupling.(https://doi.org/10.1002/chem.202000288)
Hot Paper
155. El-Halfawy, O. M.; Czarny, T. L.; Flannagan, R. L.; Day, J.; Salim, A.; Kuiack, R. C.; McGavin, J. M.; Organ, M. G.; Heinrichs, D. E.; Brown, E. D. Nature Chemical Biology. 2020, 144, 143–149. Antagonism screen uncovers anti-virulence agents that reverse β- lactam resistance in MRSA.(https://doi.org/10.1038/s41589-019-0401-8)
Hot Paper
154. Eckert. P.; Organ, M. G. Chem. Eur. J. 2019, 25, 15751-15754. The Role of LiBr and ZnBr2 on the Coupling of sp2-Hybridized Oxidative Addition Partners with sp3-Hybridized Organozincs.(https://doi.org/10.1002/chem.201903931)
Very Important Paper
153. Lombardi,C.; Champagne, P.; Rucker, R. P.; Froese, R. D. J.; Organ, M. G. Chem. Eur. J. 2019, 25,14223 –14229. Rate and Computational Studies for Pd-NHC-Catalyzed Amination with Primary Alkylamines and Secondary Anilines. Rationalizing Selectivity for Mono-Arylation vs Di-Arylation With NHC Ligands.(https://doi.org/10.1002/chem.201903362)
152. Sharif, S.; Rodriguez, M. J.; Lu, Y.; Kopach, M. E.; Mitchell, D.; Hunter, H. N.; Organ, M. G. Chem. Eur. J. 2019, 25, 13099-13103. Sodium Butylated Hydroxytoluene (NaBHT) as a new and Efficient Hydride Source for Pd-Catalysed Reduction Reaction.(https://doi.org/10.1002/chem.201902876)
151. Sinha, N.; Heijnen, D.; Feringa, B. L.; Organ, M. G. Chem. Eur. J. 2019, 25, 9180 – 9184. Murahashi cross-coupling at -78 ºC by rapid, single-shot organolithium addition; a one- pot procedure for sequential C-C/C-C, C-C/C-N, and C-C/C-S of bromo-chloro arenes.(https://doi.org/10.1002/chem.201901678)
Highlighted SYNFACT 2019, 15(10), 1109.
150. Sinha, N.; Champagne, P. A.; Rodriguez, M. J.; Lu, Y.; Kopach, M. E.; Mitchell, D.; Organ, M. G. Chem. Eur. J. 2019, 25, 6508-6512. One-Pot Sequential Kumada-Tamao- Corriu Couplings of (Hetero)Aryl Polyhalides in the Presence of Grignard-Sensitive Functional Groups Using Pd-PEPPSI-IPentCl.(https://doi.org/10.1002/chem.201901150)
149. Diner, C.; Organ, M. G. Organometallics, 2019, 38, 66-75. Invited Perspective. What Industrial Chemists Want - Are Academics Giving It To Them?(https://doi.org/10.1021/acs.organomet.8b00818)
148. Price, G.; Mallik, D.; Organ, M. G. J. Flow Chem. 2018, 8, 82-86. Process Analytical Tools for Flow Analysis.(https://d-nb.info/1160265615/34)
Spotlighted Paper
147. Sharif, S.; Day, J.; Hunter, H. N.; Lu, Y.; Mitchell, D.; Rodriguez, M. J.; Organ, M. G. J. Am. Chem. Soc. 2017,139, 18436–18439. Cross-coupling of primary amides to aryl- and heteroaryl-partners using (DiMeIHeptCl)Pd promoted by trialkylboranes or BCF. (http://doi.org/10.1021/Jacs.7B09488)
146. Price, G. A.; Hassan, A.; Chandrasoma, N.; Bogdan, A. R.; Djuric, S. W.; Organ, M. G. Angew. Chem. Int. Ed. 2017, 56. 13347-13350. Pd-PEPPSI-IPent-SiO2, a Supported Catalyst for Challenging Negishi Coupling Reactions in Flow.(https://doi.org/10.1002/anie.201708598)
145. Khadra, A.; Mayer, S.; Mitchell, D.; Rodriguez, M. J.; Organ, M. G. Organometallics 2017, 36, 3573-3577. A General Protocol for the Broad-Spectrum Cross-Coupling of Non-Activated, Sterically Hindered 1° and 2° Amines.(https://doi.org/10.1021/acs.organomet.7b00490)
144. Froese, R. D. J; Lombardi, C.; Pompeo, M.; Rucker, R. P.; Organ, M. G. Accounts of Chemical Research. 2017, 50, 2244–2253. Designing Pd-N-Heterocyclic Carbene (NHC) Complexes for High Reactivity and Selectivity for Cross-Coupling Applications.(https://doi.org/10.1021/acs.accounts.7b00249)
143. Kwak, J. S.; Zhang, W.; Tsoy, D.; Hunter, H. N.; Mallik, D.; Organ M. G. Org. Proc. Res. Dev. 2017, 21, 1051–1058. A Multi-Position Valve for Uninterrupted Sampling from Heterogeneous Slurries - An Application for Flow Chemistry.(https://doi.org/10.1021/acs.oprd.7b00166)
142. Chen, X.; Organ, M. G.; Pietro, W. Nanoscience, Adv. Technol. 2017, 2, 5. A Facile Controlled Preparation Method of Multifunctional Core-Shell Magnetic Nanoparticles by Thiol-ene Click Reactions, and Their Potential Use in Microfluidic Separations.(http://doi.org/10.24218/jnat.2017.21)
141. Khadra, A.; Mayer, S.; Organ, M. G. Chem. Eur. J. 2017, 23, 3206-3212. Pd-PEPPSI- IPentCl, A Useful Catalyst for the Coupling of 2-Aminopyridine Derivatives.(https://doi.org/10.1002/chem.201605490)
140. Lombardi, C.; Mitchell, D.; Rodriguez, M. J.; Organ, M. G. Eur. J. Org. Chem 2017, 2017, 1510-1513. Pd-PEPPSI-IPentCl Catalyzed Amination Using Aminotriphenylsilane as an Ammonia Surrogate.(https://doi.org/10.1002/ejoc.201601565)
139. Lombardi, C.; Day, J.; Chandrasoma, N.; Mitchell, D.; Rodriguez, M. J.; Farmer, J. L.; Organ, M. G. Organometallics 2017, 36, 251-254. The Selective Cross-coupling of (Hetero)aryl Halides with Ammonia to Produce Primary Arylamines using Pd-NHC Complexes.(https://doi.org/10.1021/acs.organomet.6b00830)
138. Khadra, A.; Organ, M. G. J. Flow. Chem. 2016, 6, 293-296. Generation and Use of Benzyne Intermediates for Diels-Alder Cycloaddition in Flow.
137. Teci, M.; Tilley, M.; McGuire, M. A.; Organ, M. G. Org. Proc. Res. Dev. 2016, 20, 1967- 1973. Handling hazards using continuous flow chemistry: synthesis of N1-aryl-1,2,3- triazoles from anilines via telescoped three step diazotization / azidodediazotization / [3 + 2] dipolar cycloaddition processes.(https://doi.org/10.1021/acs.oprd.6b00292)
136. Teci, M.; Tilley, M.; McGuire, M. A.; Organ, M. G. Chem. Eur. J. 2016, 22. 17405-17407. Using anilines as masked cross-coupling partners: design of a telescoped three-step flow diazotization, iododediazotization, cross-coupling process.(https://doi.org/10.1002/chem.201603626)
135. Sharif, S.; Mitchell, D.; Rodriguez, M. J.; Farmer, J. L.; Organ, M. G. Chem. Eur. J. 2016, 22. 14860-14863. N-Heteroarylation of Optically Pure α-Amino Esters using the Pd- PEPPSI-IPentCl-o-picoline Pre-catalyst.(https://doi.org/10.1002/chem.201603933)
Encyclopedia of Reagents for Organic Synthesis 2017 Best Reagent Award
134. Lombardi, C.; Organ, M. G. Encyclopedia of Reagents for Organic Synthesis (EROS) 2016. trans-[1,3-B(2,6-Di-3-pentylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(II) Dichloride (Pd-PEPPSITM-IPent).(https://doi.org/10.1002/047084289X.rn02073)
133. Atwater, B.; Chandrasoma, N.; Mitchell, D.; Rodriguez, M. J.; Organ, M. G. Chem. Eur. J. 2016, 22, 14531-14534 Pd-PEPPSI-IHeptCl: A General Purpose, Highly Reactive Catalyst for the Selective Coupling of Secondary Alkyl Organozincs.(https://doi.org/10.1002/chem.201603603)
132. Day, C.; Saledega, A.; Tilley, M.; Hunter, H. N.; Organ, M. G.; Wilson, D. J. Org. Proc. Res. Dev. 2016, 20. 1738-1743. A Continuous High Efficiency Extraction Device (HEED) for Flow Synthesis.(https://doi.org/10.1021/acs.oprd.6b00226)
131. Price, G. A.; Bogdan, A. R.; Aguirre, A. L.; Iwai, T.; Djuric, S. W.; Organ, M. G. Catalysis Science & Technology 2016, 6, 4733 – 4742. Continuous flow Negishi cross-couplings employing silica-supported Pd-PEPPSI-IPr Precatalyst.(https://doi.org/10.1039/C6CY00331A)
130. Chen, X.; Organ, M. G.; Pietro, W. J. J. Nanosci, Adv. Technol. 2016, 1, 25-31. One-pot synthesis of size controllable amine-functionalized core-shell magnetic nanoparticles for use in microfluidic flow separators.(https://doi.org/10.24218/jnat.2016.14)
129. Schruder, C. W.; Organ, M. G.; Pietro, W. J. Current Nanoscience 2016, 12, 448-454. Metal nanoparticle impregnated controlled-size silica macrospheres as a microwave- transparent catalyst system for MACOS.(http://doi.org/10.2174/1573413712666160115000726)
128. Tilley, M.; Li, G.; Savel, P.; Mallik, D.; Organ, M. G. Org. Proc. Dev. Res. 2016, 20, 517- 524. Intelligent Continuous Collection Device for High-Pressure Flow Synthesis: Design and Implementation.(https://doi.org/10.1021/acs.oprd.5b00363)
127. Sharif, S.; Rucker; R. P.; Chandrasoma, N.; Mitchell, D.; Rodriguez, M. J.; Pompeo, M.; Froese, R. D. J.; Organ, M. G. Angew. Chem. Int. Ed. 2015, 54, 9507-9511. (Angew. Chem. 2015, 127, 9643–9647). Selective Monoarylation of Primary Amines using the Pd- PEPPSI-IPentCl Precatalyst.(https://doi.org/10.1002/anie.201502822)
Article awarded frontispiece.
Highlighted in Chemical and Engineering News, July 6, 2015 issue, page 41.
126. Atwater, B.; Chandrasoma, N.; Mitchell, D.; Rodriguez, M. J.; Pompeo, M.; Froese, R. D. J.; Organ, M. G. Angew. Chem. Int. Ed. 2015, 54, 9502 –9506. (Angew. Chem. 2015, 127, 9638–9642). The Selective Cross-Coupling of Secondary Alkyl Zinc Reagents to Five-Membered-Ring Heterocycles Using Pd-PEPPSI-IHeptCl.(https://doi.org/10.1002/anie.201503941)
125. Farmer, J. L.; Froese, R. D. J.; Lee-Ruff, E.; Organ, M. G. Chem. Eur. J. 2015, 20, 1888- 1893. Solvent Choice and Kinetic Isotope Effects (KIE) Dramatically Alter Regioselectivity in the Directed Ortho Metallation (DoM) of 1,5-Dichloro-2,4- dimethoxybenzene.(https://doi.org/10.1002/chem.201405981)
124. Somerville, K.; Tilly, M.; Li, G.; Mallik, D.; Organ, M. G. Org. Proc. Dev. Res. 2014, 18, 1315-1320. A Flow Reactor with Inline Analytics: Design and Implementation.(https://doi.org/10.1021/op5002512)
123. Sauks, J. M.; Mallik, D.; Lawryshyn, Y.; Bender, T.; Organ, M. G. Org. Proc. Dev. Res. 2014, 18, 1310–1314. A Continuous Flow Microwave Reactor for Conducting High Temperature and High Pressure Chemical Reactions.(https://doi.org/10.1021/op400026g)
122. Farmer, J. L.; Pompeo, M.; Lough, A. J.; Organ, M. G. Chem. Eur. J. 2014, 20, 15790- 15798. (IPent)PdCl2(morpholine): A Readily Activated Pre-Catalyst for Room Temperature, Additive-Free Carbon-Sulfur Coupling.(https://doi.org/10.1002/chem.201404705)
Highlighted SYNFACT 2014, 10(10), 1073.
121. Oderinde, W. S.; Froese, R. D. J.; Organ, M. G. Chem. Eur. J. 2014, 20, 8579-8583. On the Hydrostannylation of Aryl Propargylic Alcohols and Their Derivatives. Remarkable Changes in Both Regio- and Stereoselectivity When Radical- and Non-Radical Mediated Transformations.(https://doi.org/10.1002/chem.201403459)
“News of the Week” in Chemical and Engineering News, April 7, 2014 issue 14, p 7.
Highlighted SYNFACT 2014, 10(7), 0736.
“Research Year in Review – Top 10 Notable Science and Engineering Advances from 2014” in Chemical and Engineering News, December 22, 2014 issue 51, p.17
120. McCann, L. A.; Organ, M. G. Angew. Chem. Int. Ed. 2014, 53, 4386-4389. (Angew. Chem. 2014, 126, 4475-4478). On The Remarkably Different Role of Salt in the Cross- Coupling of Arylzincs From That Seen With Alkylzincs.(https://doi.org/10.1002/anie.201400459)
119. Nalivela, K. S.; Tilley, M.; McGuire, M. A.; Organ, M. G. Chem. Eur. J. 2014, 20, 6603– 6607. A Multi-Component, Flow Diazotization/Mizoroki-Heck Coupling Protocol. Dispelling Myths About Working With Diazonium Salts.(https://doi.org/10.1002/chem.201402092)
118. Pompeo, M.; Farmer, J. L.; Froese, R. D. J.; Organ, M. G. Angew. Chem. Int. Ed. 2014, 53, 3223-3226. (Angew. Chem. 2014, 126, 3287-3290). Room Temperature Amination of Deactivated Aniline and Aryl Halide Partners using Carbonate Base by Pd-PEPPSI- IPentCl-o-Picoline.(https://doi.org/10.1002/anie.201310457)
117. Valente, C.; Pompeo, M.; Sayah, M.; Organ, M. G. Org. Proc. Dev. Res. 2014, 18, 180- 190. Carbon–Heteroatom Coupling Using Pd–PEPPSI Complexes.(https://doi.org/10.1021/op400278d)
116. Sayah, M.; Organ, M. G. Chem. Eur. J. 2013, 19, 16196-16199. Potassium Isopropoxide: For Sulfination, It’s the Only Base You Need.(https://doi.org/10.1002/chem.201303756)
115. Boodram, S. N.; McCann, L. C.; Organ, M. G.; Johnson, P. E. Analytical Biochemistry, 2013, 442, 231-236. Quantitative Affinity Electrophoresis of RNA-Small Molecule Interactions by Cross-Linking the Ligand to Acrylamide.(https://doi.org/10.1016/j.ab.2013.07.040)
Highlighted in Chemical and Engineering News, August 18, 2014 issue, page 24.
114. Oderinde, M. S.; Froese, R. D. J.; Organ, M. G. Angew. Chem. Int. Ed. 2013, 52, 11334-11338. (Angew. Chem. 2013, 125, 11544-11548) 2,2’-Azobis(2-methylpropionitrile)-Mediated Alkyne Hydrostannylation: Reaction Mechanism.(https://doi.org/10.1002/anie.201303736)
113. Hoi, K. H.; Coggan, J. A.; Organ, M. G. Chem. Eur. J. 2013, 19, 843–845. Pd-PEPPSI-IPentCl: An Effective Catalyst for the Preparation of Triarylamines.(https://doi.org/10.1002/chem.201203379)
Highlighted SYNFACT 2014, 10(7), 0736.
112. Oderinde, M. S.; Organ, M. G. Chem. Eur. J. 2013, 19, 2615–2618. Pronounced Solvent Effect on the Hydrostannylation of Propargylic Alcohol Derivatives with nBu3SnH/Et3B at Room Temperature.(https://doi.org/10.1002/chem.201203405)
111. Sayah, M.; Lough, A.; Organ, M. G. Chem. Eur. J. 2013, 19, 2749-2756. Sulfination By Pd-PEPPSI Complexes: Studies Into Pre-catalyst Activation, Cationic and Solvent Effects, and Role of Butoxide Base.(https://doi.org/10.1002/chem.201203142)
110. Farmer, J.; Hunter, H. N.; Organ, M. G. J. Am. Chem. Soc. 2012, 134, 17470−17473. Regioselective Cross-Coupling of Allylboronic Acid Pinacol Ester Derivatives with Aryl halides via Pd-PEPPSI-IPent.(https://doi.org/10.1021/ja308613b)
109. Tsimerman, M.; Mallik, D.; Matsuo, T.; Otani, T.; Tamao, K. Organ, M. G. Chem. Commun. 2012, 48, 10352-10354. Sterically demanding imidazolinium salts through a one-pot activation and cyclization of formamides.(http://doi.org/10.1039/c2cc36329a)
108. Pompeo, M.; Froese, R. D. J.; Hadei, N.; Organ, M. G. Angew. Chem. Int. Ed. 2012, 51, 11354 –11357. (Angew. Chem. 2012, 124, 11516-11519) Pd-PEPPSI-IPentCl: An Effective Catalyst for the Cross-Coupling of Secondary Organozinc Reagents.(https://doi.org/10.1002/anie.201205747)
107. Oderinde, M. S.; Organ, M. G. Angew. Chem. Int. Ed. 2012, 51, 9834-9837 (Angew. Chem. 2012, 124, 9972-9975). Studies on the Mechanism of B(C6F5)3-Catalyzed Hydrostannylation of Propargylic Alcohol Derivatives.(https://doi.org/10.1002/anie.201204060)
106. Faisal, S.; Ullah, F.; Maity, P. K.; Rolfe, A.; Samarakoon, T. B.; Porubsky, P.; Neuenswander, B.; Lushington, G. H.; Basha, F. Z.; Organ, M. G.; Hanson , P. R. ACS Comb. Sci. 2012, 14, 268-272. Facile (Triazolyl)methylation of MACOS-derived Benzofused Sultams Utilizing ROMP-derived OTP Reagents.(https://doi.org/10.1021/co2001839)
105. Oderinde, M. S.; Hunter, H. N.; Organ, M. G. Chem. Eur. J. 2012, 18, 10817-10820. Kinetic versus Thermodynamic Stereoselectivity in the Hydrostannylation of Propargylic Alcohol Derivatives Using AIBN and Et3B as Promotors.(https://doi.org/10.1002/chem.201202099)
104. Oderinde, M. S.; Hunter, H. N.; Froese, R. D. J.; Organ, M. G. Chem. Eur. J. 2012, 18, 10821-10824. Highly Stereo- and Regioselective Hydrostannylation of Internal Alkynes Catalysed by Simple Boric Acid in Air.(https://doi.org/10.1002/chem.201202100)
103. Ullah, F.; Zang, Q.; Javed, S.; Zhou, A.; Knudtson, C. A.; Bi, D.; Hanson, P. R.; Organ, M. G. 2012, J. Flow. Chem. 2, 118-123. Multicapillary Flow Reactor: Synthesis of 1,2,5-thiadiazepane 1,1-dioxides Library Utilizing One Pot Elimination and Inter-/Intramolecular Double aza-Michael Addition Via Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS). (https://doi.org/10.1556/jfc-d-12-00015)
102. Zang, Q.; Javed, S.; Hill, D.; Ullah, F.; Bi, D.; Porubsky, P.; Neuenswander, B.; Lushington, G. H.; Santini, C.; Organ, M. G.; Hanson, P. R. ACS Combi. Sci. 2012, 14, 456–459. Automated Synthesis of a Library of Triazolated 1,2,5-Thiadiazepane 1,1-Dioxide via a Double aza-Michael Strategy.(https://doi.org/10.1021/co300049u)
Highlighted in Chemical and Engineering News, June 18, 2012 issue, page 32.
101. McCann, L. C,; Hunter, H. N.; Clyburne, J. A. C.; Organ, M. G. Angew. Chem. Int. Ed. 2012, 51, 7024-7027 (Angew. Chem. 2012, 124, 7130-7133). Higher-Order Zincates as Transmetallators in Alky-Alkyl Negishi Cross-Coupling.(https://doi.org/10.1002/anie.201203547)
100. Ullah, F.; Zang, Q.; Javed, S.; Porubsky, P.; Neuenswander, B.; Lushington, G. H.; Bash, F. Z.; Hanson, P. R.; Organ, M. G. Synthesis 2012, 44, 2547-2554. Synthesis of Isoindoline Annulated Tricyclic Sultams Library via Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS).(https://doi.org/10.1055/s-0031-1289791)
99. Zang, Q.; Javed, S.; Porubsky, P.; Ullah, F.; Neuenswander, B.; Lushington, G. H.; Basha, F. Z.; Organ, M. G.; Hanson, P. R. ACS Combi. Sci. 2012, 14, 211–217. Synthesis of a Unique Isoindoline/Tetrahydroisoquinoline-based Tricyclic Sultam Library Utilizing a Heck-aza-Michael Strategy.(https://doi.org/10.1021/co200181x)
98. Valente, C.; Çalimsiz, S.; Hoi, K. H.; Mallik, D.; Sayah, M.; Organ, M. G. Angew. Chem. Int. Ed. 2012, 51, Invited Article. 3314-3332 (Angew. Chem. 2012, 124, 2012, 3370–3388). The Development of Bulky Palladium NHC Complexes for the Most-Challenging Cross Coupling Reactions.(https://doi.org/10.1002/anie.201106131)
97. Hoi, K. H.; Organ, M. G. Chem. Eur. J. 2012, 18, 804-807. Potassium 2,2,5,7,8-Pentamethylchroman-6-oxide: A Rationally-Designed Base for Pd-Catalysed Amination.(https://doi.org/10.1002/chem.201103284)
96. Oderinde, M.; Hunter, H. N.; Bremner, S.; Organ, M. G. Eur. J. Org. Chem. 2012, 175–182. Iodolactonization: Synthesis, Stereocontrol and Compatibility Studies.(https://doi.org/10.1002/ejoc.201101343)
95. Hoi, K. H.; Çalimsiz, S.; Froese, R. D. J.; Hopkinson; A. C.; Organ, M. G. Chem. Eur. J. 2012, 18, 145-151. Amination with Pd-NHC Complexes: Rate and Computational Studies Involving Substituted Aniline Derivatives.(https://doi.org/10.1002/chem.201102428)
94. Sayah, M.; Organ, M. G. Chem. Eur. J. 2011, 17, 11719-11722. Carbon-Sulfur Bond Formation of Challenging Substrates at Low Temperature Using Pd-PEPPSI-IPent.(https://doi.org/10.1002/chem.201102158)
93. Organ, M. G.; Rogers, L.; Konstantinou, Z.; Reddy, M. Eur. J. Org. Chem. 2011, 5374-5382. The Synthesis of Stereodefined Trisubstituted Olefins From Olefin Templates Using Pd Catalysis- Synthesis of the Antihupertensive Isbogrel.(https://doi.org/10.1002/ejoc.201100849)
92. Painter, T. O.; Thornton, P. D.; Orestano, M.; Santini, C.; Organ, M. G.; Aubé, J. Chem. Eur. J. 2011, 17, 9595-9598. In Situ Generation and Intramolecular Schmidt Reaction of Keto Azides in a Microwave-Assisted Flow Format.(https://doi.org/10.1002/chem.201100768)
91. Rolfe, A.; Ullah, F.; Samarakoon , T. B.; Kurtz, R. D.; Porubsky, P.; Neuenswander, B.; Lushington, G. H.; Santini, C.; Organ, M. G.; Hanson, P. R. ACS Comb. Sci., 2011, 13, 653–658. Synthesis of Amino-Benzothiaoxazepine-1,1-dioxides Utilizing a Microwave-Assisted, SNAr Protocol.(https://doi.org/10.1021/co200076j)
90. Organ M. G.; Hanson, P. R.; Rolfe, A.; Samarakoon, T. B.; Ullah F.J. Flow Chem. 2011, 1, 32-39. Accessing Stereochemically Rich Sultams via Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS) Scale-out.(https://doi.org/10.1556/jfchem.2011.00008)
Invited Inside Cover
89. Hunter, H. N.; Hadei, N.; Blagojevic, V.; Patschinski, P.; Achonduh, G. T.; Avola, S.; Bohme, D. K.; Organ, M. G. Chem. Eur. J. 2011, 17, 7845-7851. Identification of a Higher-Order Organozincate Intermediate Involved in Negishi Cross-Coupling Reactions by Mass Spectrometry and NMR Spectroscopy.(https://doi.org/10.1002/chem.201101029)
88. Zang, Q.; Javed, S.; Ullah, F. Zhou, A.; Knudtson, C. A.; Bi, D.; Basha, F. Z.; Organ, M. G.; Hanson, P. Synthesis, 2011, 2743-2750. Application of a Double aza-Michael Reaction in a “Click, Click, Cy-Click” Strategy: From Bench to Flow.(https://doi.org/10.1055/s-0030-1260112)
87. Hoi, K. H.; Çalimsiz, S.; Froese, R. D. J.; Hopkinson; A. C.; Organ, M. G. Chem. Eur. J. 2011, 17, 3086-3090. Amination with Pd-NHC Complexes: Rate and Computational Studies on the Effects of the Oxidative Addition Partner.(https://doi.org/10.1002/chem.201002988)
HOT ARTICLE
Invited Front Cover (declined due to cost)
86. Hadei, N.; Achonduh, G. T.; Valente, C.; O’Brien, C. J.; Organ, M. G. Angew. Chem. Int. Ed. 2011, 50, 3896 –3899. (Angewandte Chemie, 2011, 123, 3982-3985) Differentiating C–Br and C–Cl bond activation using solvent polarity: Applications to orthogonal alkyl–alkyl Negishi reactions.(https://doi.org/10.1002/ange.201100705)
85. Çalimsiz, S.; Organ, M. G. Chem. Commun. 2011, 47, 5181-5183. Negishi Cross-Coupling of Secondary Alkylzinc Halides with Aryl/Heteroaryl Halides using Pd-PEPPSI-IPent.(https://doi.org/10.1039/C0CC04835F)
84. Batruch, I.; Javasky, E.; Brown, E. D.; Organ, M. G.; Johnson, P. Bioorg. Med. Chem. 2010, 18, 8485-8492. Thermodynamic and NMR Analysis of Inhibitor Binding to Dihydrofolate Reductase.(https://doi.org/10.1016/j.bmc.2010.10.048)
83. Achanta, S.; Liautard, V.; Paugh, R.; Organ, M. G. Chem. Eur. J. 2010, 16, 12797-12800. The Development of a General Strategy for the Synthesis of Tyramine-Based Natural Products Using Continuous Flow Techniques.(https://doi.org/10.1002/chem.201002102)
82. Ullah, F.; Samarakoon, T.; Rolfe, A.; Kurtz, R. D.; Hanson, P. R.; Organ, M. G. Chem. Eur. J. 2010, 16, 10959-10962. Scaling Out by Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS): Multi-Gram Synthesis of Bromo- and Fluoro-benzofused Sultams Benzthiaoxazepine-1,1-dioxides.(https://doi.org/10.1002/chem.201001651)
81. Nasielski, J.; Hadei, N.; Achonduh, G.; Kantchev, E. A. B.; O’Brien, C. J.; Organ, M. G. Chem. Eur. J. 2010, 16, 10844-10853. Structure–Activity Relationship Analysis of Pd–PEPPSI Complexes in Cross-Couplings: A Close Inspection of the Catalytic Cycle and the Precatalyst Activation Model.(https://doi.org/10.1002/chem.201000138)
80. Achonduh, G. T.; Hadei, N.; Valente, C.; Avola, S.; O’Brien, C. J.; Organ, M. G. Chem. Commun. 2010, 46, 4109-4111. On the role of additives in alkyl–alkyl Negishi cross-couplings.(https://doi.org/10.1039/C002759F)
79. Valente, C.; Belowich, M. E.; Hadei, N.; Organ, M. G. Eur. J. Org. Chem. 2010, 23, 4343-4354. Invited Article. Pd-PEPPSI Complexes and the Negishi Reaction. Most downloaded in first quarter.(https://doi.org/10.1002/ejoc.201000359)
78. Shore, G.; Organ, M. G. Gold Bulletin, 2010, 43, 105-113. Panning for Gold in a Hot Flowing Stream.(https://doi.org/10.1007/BF03214975)
77. Çalimsiz, S.; Sayah, M.; Mallik, D.; Organ, M. G. Angew. Chem. 2010, 122, 2058–2061; Angew. Chem. Int. Ed. 2010, 49, 2014–2017. Pd-PEPPSI-IPent: Room Temperature Negishi Cross-Coupling for the Preparation of Highly Functionalized, Tetra-Ortho Substituted Biaryls.(https://doi.org/10.1002/anie.200906811)
76. Dowlut, M.; Mallik, D.; Organ, M. G. Chem. Eur J. 2010, 15, 4279-4283. An Efficient Low Temperature Stille-Migita Cross-Coupling Reaction for Heteroaromatic Compounds by Pd-PEPPSI-IPent."(https://doi.org/10.1002/chem.200903337)
Featured Research Highlight in Nature 2010,Vol 464/8, P117.
75. Shore, G.; Yoo, W. J.; Li, C. J.; Organ, M. G. Chem. Eur. J. 2010, 16, 126-133. Invited Inside Front Cover Article: Propargyl Amine Synthesis Catalysed by Gold and Copper Thin Films Using Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS)(https://doi.org/10.1002/chem.200990200)
74. Shore, G.; Tsimerman, M.; Organ, M. G. Beilstein J. Org. Chem. 2009, 5, No. 35. Gold Film-Catalysed Benzannulation by Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS).(https://doi.org/10.3762/bjoc.5.35)
73. Chass, G. A.; O'Brien, C. J.; Hadei, N.; Kantchev, E. A. B.; Mu, W.-H.; Fang, D.-C.; Hopkinson, A. C.; Csizmadia, I. G.; Organ, M. G. Chem. Eur. J. 2009, 15, 4281-4288. Density Functional Theory (DFT) Investigation of the Alkyl-Alkyl Negishi Cross-Coupling Reaction Catalyzed by N-heterocyclic Carbene (NHC)-Pd Complexes.(https://doi.org/10.1002/chem.200900042)
72. M. G. Organ, S. Çalimsiz, M. Sayah, K. H. Hoi and A. J. Lough, Angew. Chem. 2009, 121, 2419–2423; Angew. Chem. Int. Ed. 2009, 48, 2383–2387. PEPPSI-Isopentyl: A Highly Active, Sterically Demanding Cross-Coupling Catalyst and Its Application in the Synthesis of Tetra-Ortho-Substituted Biaryls.(https://doi.org/10.1002/anie.200805661)
71. Shore, G.; Organ, M. G. Chem. Eur. J. 2008, 14, 9641-9646. Gold-film-catalysed hydrosilylation of alkynes by microwave-assisted, continuous flow organic synthesis (MACOS).(https://doi.org/10.1002/chem.200801610)
70. Organ, M. G.; Chass, G. A.; Fang, D.-C.; Hopkinson, A. C.; Valente, C. Synthesis, 2008, 2776-2797. Pd-NHC (PEPPSI) Complexes: Synthetic Utility and Computational Studies into their Reactivity.(http://doi.org/10.1002/chin.200849238)
69. Valente, C.; Organ, M. G. Chem. Eur. J. 2008, 14, 8239-8245. Assessing Synthetic Strategies: Total Syntheses of (±)-Neodolabellane-Type Diterpenoids.(https://doi.org/10.1002/chem.200801161)
68. Abdel-Hadi, M.; Avola, S.; Dubovyk, I.; Hadei, N.; Kantchev, E. A. B.; O’Brien, C. J.; Sayah, M.; Valente, C.; Organ, M. G. Chem. Eur. J. 2008, 14, 2443-2452. Pd-Catalyzed Aryl Amination Mediated By Well Defined, N-Heterocyclic Carbene (NHC)-Pd Precatalysts, PEPPSI™.(https://doi.org/10.1002/chem.200701621)
67. Valente, C.; Baglione, S.; Candito, D.; O’Brien, C. J; Organ, M. G. Chem. Commun. 2008, 735-737. High yielding alkylations of unactivated sp3 and sp2 centers with alkyl-9-BBN reagents using an NHC-based catalyst: Pd-PEPPSI-IPr.(https://doi.org/10.1039/B715081D)
66. Shore, G.; Organ, M. G. Chem. Commun. 2008, 838-840. Diels-Alder cycloadditions by microwave-assisted, continuous flow organic synthesis (MACOS): The role of metal films in the flow tube.(https://doi.org/10.1039/B715709F)
65. Shore, G.; Morin, S.; Mallik, D.; Organ, M. G. Chem. Eur. J. 2008, 14, 1351-1356. Pd PEPPSI-IPr-Mediated Reactions in Metal-Coated Capillaries Under Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS): The Synthesis of Indoles by Sequential Aryl Amination/Heck Coupling.(https://doi.org/10.1002/chem.200701588)
64. Bremner, S.; Organ, M. G. J. Comb. Chem. 2008, 10, 142-147. Formation of substituted pyrroles via an imine condensation/aza-Claisen rearrangement/imine-allene cyclization process by MAOS.(https://doi.org/10.1021/cc700159u)
63. Bremner, S.; Organ, M. G. J. Comb. Chem. 2007, 9, 14-16. Multi-Component Reactions (MCR) to Form Heterocycles by Microwave-Assisted Continuous Flow Organic Synthesis (MACOS). Second most highly cited article in J. Comb. Chem. for 2007.(https://doi.org/10.1021/cc060130p)
Publication is a citation classic.
62. Kantchev, E. A. B.; O’Brien, C. J.; Organ, M. G. Angew. Chem. 2007, 119, 2824-2870; Angew. Chem. Int. Ed. 2007, 46, 2768-2813. Invited Article. Pd-N-heterocyclic carbene (NHC) Catalysts for Cross-Coupling Reactions - The Synthetic Chemist’s Perspective."(https://doi.org/10.1002/anie.200601663)
Publication is a citation classic.
61. Organ, M. G.; Abdel-Hadi, M.; Avola, S.; Hadei, N.; Nasielski, J.; O’Brien, C. J.; Valente, C. Chem. Eur. J., 2007, 13, 150-157. Biaryls Made Easy: PEPPSI and the Kumada-Tamao-Corriu Reaction.(https://doi.org/10.1002/chem.200601360)
60. Kantchev, E. A. B.; O’Brien, C. J.; Organ, M. G. Aldrichimica Acta 2006, 39, 97-111. Invited Article. Pd-N-Heterocyclic Carbene (NHC) Catalysts for Cross-Coupling Reactions.(https://doi.org/10.1021/acs.accounts.7b00249)
59. Summerfield, R.; Daigle, D.; Mayer, S.; Hughes, D.; Jackson, S.; Sulek, M.; Mallik, D.; Organ, M. G.; Brown, E.; Junop, M. J. Med. Chem. 2006, 49, 6977-6986. A 2.13 Å Structure of E. coli DHFR Bound to a Novel Competitive Inhibitor Reveals a New Binding Surface involving the M20 Loop Region.(https://doi.org/10.1021/jm060570v)
Most highly downloaded article in Chem. Eur. J. for 2006.
58. O’Brien, C. J.; Kantchev, E. A. B.; Hadei, N.; Valente, C. Chass, G. A.; Nasielski, J. C.; Lough, A.; Hopkinson, A. C.; Organ, M. G. Chem. Eur. J., 2006, 12, 4743-4748. Front-Cover Article: Easily Prepared Air- and Moisture-Stable Pd-NHC (NHC = N-Heterocyclic carbene) Complexes: A reliable, User-Friendly, Highly Active Palladium Precatalyst for the Suzuki-Miyaura Reaction. (https://doi.org/10.1002/chem.200600251)
Second most highly downloaded article in Chem. Eur. J. for 2006.
57. Organ, M. G.; Avola, S.; Dubovyk, I.; Hadei, N.; Kantchev, E. A. B.; O’Brien, C. J.; Valente, C. Chem. Eur. J., 2006, 12, 4749-4755. Front-Cover Article : A User-friendly, All-purpose Pd-NHC Precatalyst for the Negishi Reaction: A Step Towards an Universal Cross-coupling Catalyst. Second most highly downloaded article in Chem. Eur. J. for 2006.(https://doi.org/10.1002/chem.200600206)
56. Kantchev, E. A. B.; O’Brien, C. J.; Organ, M. G. ChemFiles 2006, 6, 1-9. Invited Article. Catalysis: PEPPSI TM Catalyst.
55. Shore, G.; Morin, S.; Organ, M. G. Angew. Chem. 2006, 118, 2827-2832 (Angew. Chem. Int. Ed. 2006, 45, 2761-2766). Catalysis in Capillaries by Pd Thin Films Using Microwave-Assisted Continuous Flow Organic Synthesis (MACOS).(https://doi.org/10.1002/ange.200503600)
54. Mallik, D.; Organ, M. G. Can. J. Chem. 2006, Invited Article, 84, 1259-1262. A Silyl-Mediated [3+2] Photochemical Cycloaddition.(https://doi.org/10.1139/v06-077)
53. Hadei, N.; Kantchev, E. A. B.; O’Brien, C. J. Organ, M. G. J. Org. Chem. 2005, 70, 8503-8507. Room Temperature Negishi Cross-coupling of Unactivated Alkyl Bromides with Alkyl Organozinc Reagents Utilizing a Pd-N-Heterocyclic Carbene Catalyst.(https://doi.org/10.1021/jo051304c)
52. O'Brien, C. J.; Kantchev, E. A. B.; Chass, G. A.; Hadei, N.; Hopkinson, A. C.; Organ, M. G.; Setiadi, D. H.; Tang, T.-H.; Fang, D.-C. Tetrahedron 2005, 61, 9723-9735. Invited Perspective Paper. Towards the Rational Design of Palladium-N-Heterocyclic Carbene Catalysts by a Combined Experimental and Computational Approach.(https://doi.org/10.1016/j.tet.2005.07.101)
51. Organ, M. G.; Comer, E. Chem. Eur. J. 2005, 11, 7223-7227. A Microcapillary System for Microwave Assisted, High Throughput Synthesis of Molecular Libraries.(https://doi.org/10.1002/chem.200500820)
50. Hadei, N.; Kantchev, E. A. B.; O’Brien, C. J. Organ, M. G. Org.Lett. 2005, 7, 3805-3807. The First Negishi Cross-Coupling Reaction of Two Alkyl Centers Utilizing a Pd-N-Heterocyclic Carbene (NHC) Catalyst.(https://doi.org/10.1021/ol0514909)
49. Comer, E.; Organ, M. G. J. Am. Chem. Soc. 2005, 127, 8160-8167. A Microreactor for Microwave-Assisted Capillary (Continuous Flow) Organic Synthesis (MACOS).(https://doi.org/10.1021/ja0512069)
48. Hadie, N.; Kantchev, E.; O’Brien, C.; Organ, M. G. Org. Lett. 2005, 7, 1991-1994. Electronic Nature of N-Heterocyclic Carbene Ligands: Effect on the Suzuki Reaction.(https://doi.org/10.1021/ol050471w)
47. Organ, M. G.; Comer, E.; Hynes, S. J. J. Am. Chem. Soc. 2004, 126, 16087-16092. Allylic Ionization vs. Oxidative Addition into Vinyl C-X Bonds by Pd With Polyfunctional Olefin Templates.(https://doi.org/10.1021/ja045416h)
46. Ghasemi, H.; Valente, C.; Organ, M. G. Tetrahedron 2004, 60, 9453-9461. The Effect of Vicinyl Olefinic Halogens on Cross Coupling Reactions Using Pd (0) Catalysis."(http://doi.org/10.1016/j.tet.2004.08.006)
45. Ghasemi, H.; Antunes, L. M.; Organ, M. G. Org.Lett. 2004, 6, 913-2916. The Use of Olefin Templates in Queued Chemical Transformations Using Late Transition Metal Catalysis. The Total Synthesis of cis and trans Bupleurynol via a Single Multi-Reaction Sequence.(https://doi.org/10.1021/ol0489853)
44. Mayer, S.; Daigle, D. M.; Brown, E. D.; Khatri, J.; Organ, M. G. J. Comb. Chem. 2004 6, 776-782. An Expedient and Facile One-Step Synthesis of a Biguanide Library by Microwave Irradiation Coupled With Simple Product Filtration. Inhibitors of Dihydrofolate Reductase (DHFR).(https://doi.org/10.1021/cc049953+)
43. Hodgson, R.; Chen, Y.; Zhang, Z.; Tleugabulova, D.; Long,H.; Zhoa, X.; Organ, M. G.; Brook, M. A.; Brennan, J. D. Anal. Chem. 2004, 2780-2790. Protein-Doped Monolithic Silica Columns for Capillary Liquid Chromatography Prepared by the Sol-Gel Method.(https://doi.org/10.1021/ac0352124)
42. Organ, M. G.; Ghasemi, H. J. Org. Chem. 2004, 69, 695-700. Metal-Catalyzed Coupling Reactions on an Olefin Template: The Total Synthesis of (13E,15E,18Z,20Z)-1-hydroxypentacosa-13,15,18,20-tetraen-11-yn-4-one 1-acetate.(https://doi.org/10.1021/jo035376k)
41. Organ, M. G.; Antunes, L. M. Tetrahedron Lett. 2003, 44, 6805-6808. Metal-Catalyzed Coupling Reactions on an Olefin Template: The Total Synthesis of Bupleurynol.(https://doi.org/10.1016/S0040-4039(03)01753-2)
40. Organ, M. G.; Wang, J. J. Org. Chem. 2003, 68, 5568-5574. The Synthesis of Deoxyfusapyrone. 2. Preparation of the Bis Trisubstituted Olefin Fragment and Its Attachment to the Pyrone Moiety.(https://doi.org/10.1021/jo034371k)
39. Organ, M. G.; Arvanitis, E. A.; Villani, A.; Majkut, Y.; Hynes, S. Tetrahedron Lett. 2003, 44, 4403-4406. "Differentiating Allylic and Vinylic Leaving Groups for Pd Catalysis. The Use of Vinyl Iodide to Facilitate Room Temperature Activation of a Vinyl C-X Bond in The Presence of Allyl Carbonate.(http://dx.doi.org/10.1016%2FS0040-4039(03)00881-5)
38. Organ, M. G.; Arvanitis, E. A.; Hynes, Stephen J. J. Org. Chem. 2003, 68, 3918-3922. On the Regiochemistry of Nucleophilic Attack on 2-Halo i-Allyl Complexes. 4. The Effect of Silver Acetate and Nucleophile Concentrations in Competitive Nucleophilic Attack with Malonate and Phenoxide Nucleophiles.(https://doi.org/10.1021/jo034119c)
37. Organ, M. G.; Mayer, S. J. Comb. Chem. 2003, 5, 118-124. Synthesis of 4-(5-Iodo-3-Methylpyrazolyl) Phenylsulfonamide and Its Elaboration To a COX II Inhibitor Library by Solution-Phase Suzuki Coupling Using Pd/C as a Solid-Supported Catalyst.(https://doi.org/10.1021/cc020045r)
36. Organ, M. G.; Mayer, S.; Lepifre, F.; N'Zemba, B.; Khatri, J. Mol. Diversity, 2003, 7, 211-227. Combining The Use of Solid-Supported Transition Metal Catalysis With Microwave Irradiation In Solution-Phase Parallel Library Synthesis.(https://doi.org/10.1023/b:modi.0000006826.91512.83)
35. Organ, M. G.; Arvanitis, E. A.; Hynes, S. J. Tetrahedron Lett. 2002 43, 8989-8992. On the Regiochemistry of Nucleophilic Attack on 2-Halo i-Allyl complexes. 3. The Electronic Effect of Phenoxide Ion and the Ligand.(https://doi.org/10.1016/S0040-4039(02)02183-4)
34. Organ, M. G.; Wang, J. J. Org. Chem. 2002 67, 7847 - 7851. The Synthesis of Deoxyfusapyrone. 1. An Approach to the Pyrone Moiety.(https://doi.org/10.1021/jo0204707)
33. Organ, M. G.; Xu, J., N'Zemba, B. M. Tetrahedron Lett. 2002 43, 8177-8180. A General and Enantiospecific Strategy for the Synthesis of CVS 1778 and Its Analogs: Inhibitors of Factor Xa.(https://doi.org/10.1016/S0040-4039(02)01924-X)
32. Organ, M. G.; Buon, C.; Combs, A.; Decicco, C. P. Org. Letters 2002, 4, 2683 -2685. A Concise Synthesis of Silanediol-Based Dipeptide Transition-Sate Inhibitors of Proteases.(https://doi.org/10.1021/ol026195s)
31. Organ, M. G.; Bilokin, Y. V.; Bratovanov, S. J. Org. Chem. 2002, 67, 5176-5183. Approach Toward the Total Synthesis of Orevactaene. Part 2. Convergent and Stereoselective Synthesis of the C18–C31 Domain of Orevactaene. Evidence for the Relative Configuration of the Side Chain.(https://doi.org/10.1021/jo0201777)
30. Organ, M. G.; Arvanitis, E.A.; Dixon, C.; Cooper, J.T. J. Am. Chem. Soc. 2002, 124, 1288-1294. Controlling Chemoselectivity in Vinyl and Allylic C-X Bond Activation With Palladium Catalysis: A pKa-Based Electronic Switch.(https://doi.org/10.1021/ja011508k)
29. Organ, M. G.;* Dixon, C.E.; Mayhew, D.; Parks, D. J.; Arvanitis, E. A. Combinatorial Chemistry and High Throughput Screening. 2002, 5, 209-216. Invited Feature Article Entitled: The Use of Strong Cat-Ion Exchange (SCX) Chromatography to Purify a Variety of Structurally-Diverse Molecular Libraries Prepared by Solution Phase Methods.(https://doi.org/10.2174/1386207024607301)
28. Organ, M.G.; Arvanitis, E.A.; Dixon, C.; Lavorato, D.J.; Siegel, M.G.; Dressman, B.A. J. Comb. Chem. 2001, 3, 473-476. Solution Phase Synthesis of an Aminomethyl-Substituted Biaryl Library Via Sequential N-Alkylation and Suzuki Cross Coupling.(https://doi.org/10.1021/cc010018l)
27. Organ, M.G.; Mayhew, D.; Cooper, J.T.; Dixon, C.E.; Lavorato, D.J.; Kaldor, S.W.; Siegel, M.G. J. Comb. Chem. 2001, 3, 64-67. The Solution Phase Synthesis of Libraries of Variably Substituted Olefin Scaffolds: A Library of Allylic Amines.(https://doi.org/10.1021/cc0000601)
26. Organ, M.G.; Kaldor, S.W.; Dixon, C.; Parks, D.J.; Singh, U.; Lavorato, D.J.; Isbester, P.K.; Siegel, M.G. Tetrahedron Lett. 2000, 41, 8407-8411. The Synthesis of Ethanolamine Libraries from Olefin Scaffolds.(https://doi.org/10.1016/S0040-4039(00)01503-3)
25. Organ M.G.; Cooper, J.T.; Rogers, L.R., Soleymanzadeh, F.; Paul, T. J. Org. Chem. 2000, 65, 7959-7970. The Synthesis of Stereodefined Polysubstituted Olefins. 1. Tandem Intermolecular Reactions Involving Selective, Sequential Insertion of Pd (0) Into Allylic and Vinylic Halide Bonds. The Stereoselective Synthesis of Disubstituted Olefins.(https://doi.org/10.1021/jo001045l)
24. Organ, M.G.; Bratovanov, S. Tetrahedron Lett. 2000, 41, 6945-6949. Approach Toward the Total Synthesis of Orevactaene. 1. Assembly of the Contiguous Trisubstituted Olefin Component.(https://doi.org/10.1016/S0040-4039(00)01189-8)
23. Organ, M.G.; Dragan, V.; Miller, M.; Froese, R.D.J.; Goddard, J.D. J. Org. Chem. 2000, 65, 3666-3678. Sakurai Addition and Ring Annulation of Allylsilanes with a,b-Unsaturated Esters. Experimental Results and Ab Initio Theoretical Predictions Examining Allylsilane Reactivity.(https://doi.org/10.1021/jo991177i)
22. Organ, M.G.; Dixon, C.E. Biotechnol. Bioeng. (Combinatorial Chemistry) 2000, 71-78. Invited Feature Article Entitled: The Preparation of Amino-Substituted Biaryl Libraries. The Application of Solid-Supported Reagents to Streamline Solution Phase Synthesis.(https://doi.org/10.1002/(sici)1097-0290(200024)71:1%3C71::aid-bit10%3E3.0.co;2-u)
21. Organ, M.G.; Miller, M.; Konstantinou, Z. J. Am. Chem. Soc. 1998, 120, 9283-9290. On the Mechanism of Nucleophilic Attack on 1- and 2-Bromo(p-Allyl)palladium Complexes.(https://doi.org/10.1021/ja9801442)
20. Organ, M.G.; Miller, M. Tetrahedron Lett. 1997, 38, 8181-8184. New Reactions Involving Palladacyclobutanes: The Attack of Phenoxide Ion at the Central Carbon of Both 1- and 2- Bromo(p-Allyl)palladium Complexes.(https://doi.org/10.1016/S0040-4039(97)10252-0)
19. Organ, M.G.; Winkle, D.D.; Huffmann, J. J. Org. Chem. 1997, 62, 5254-5266. Tandem Transformations Involving Allylic Silanes. 2. Highly Diastereoselective Substitutions Involving [(Trialkylsilyl)methyl]-cyclohexene Derivatives With Aldehydes. Synthetic Studies on the Problem of Lewis Acid Promoted Protodesilylation and Enolization.(https://doi.org/10.1021/jo970821v)
18. Organ, M.G.; Winkle, D. J. Org. Chem. 1997, 62, 1881-1885. Non-Cascade Tandem Transformations Involving Allylic Silanes. 1. Pericyclic and Ionic Reactions Combined into "One-Pot" Sequences.(https://doi.org/10.1021/jo962025f)
17. Organ, M.G.; Murray, A.P. J. Org. Chem. 1997, 62, 1523-1526. Ni-Catalyzed Cross Coupling of Alkoxide-Containing Vinylhalides With Grignard Reagents. A "One-Pot" Synthesis of 2-[(Trimethylsilyl)methyl]-2-propen-1-yl acetate.(https://doi.org/10.1021/jo961900u)
16. Organ, M.G.; Anderson, P. J. Chem. Ed. 1996, 73, 1193-1196. Carbonyl and Conjugate Additions to Cyclohexenone. Experiments Illustrating Reagent Selectivity.(https://doi.org/10.1021/ed073p1193)
15. Lange, G.L.; Organ, M.G. J. Org. Chem. 1996, 61, 5358-5361. Use of Cyclic b-Keto Ester Derivatives in Photoadditions. Synthesis of (+/-) Norasteriscanolide.(https://doi.org/10.1021/jo960088s)
14. Froese, R.D.; Organ, M.G.; Stack, T.D.P.; Trost, B.M.; Goddard, J.D. J. Am. Chem. Soc. 1995, 117, 10931-10938. Theoretical and Experimental Studies of the Diels-Alder Dimerization of Substituted Cyclopentadienes.(http://doi.org/10.1002/chin.199611077)
13. Trost, B.M.; Organ, M.G.; O'Doherty, G. J. Am. Chem. Soc. 1995, 117, 9662-9670. Asymmetric Synthesis of Allylic Sulfones. Useful Asymmetric Building Blocks.(https://doi.org/10.1021/ja00143a007)
12. Trost, B.M.; Organ, M.G. J. Am. Chem. Soc. 1994, 116, 10320-10321. Deracemization of Cyclic Allyl Esters.(https://doi.org/10.1021/ja00101a070)
11. Trost, B.M.; Breit, B.; Organ, M.G.; Tetrahedron Lett. 1994, 35, 5817-5820. On the Nature of the Asymmetric Induction in a Palladium-Catalyzed Allylic Alkylation.(https://doi.org/10.1016/S0040-4039(00)78192-5)
10. Organ, M.G.; Froese, R.D.J.; Goddard, J.D.; Taylor, N.J.; Lange, G.L. J. Am. Chem. Soc. 1994, 116, 3312-3323. Photoadditions and Dialkylcuprate Additions to 2-t-Butyl-2,6-dimethyl-1,3-dioxin-4-one and Related Heterocycles. Experimental, Ab Initio Theoretical and X-ray Structure Studies of Facial Selectivity and Enone Pyramidalization.(https://doi.org/10.1021/ja00087a018)
9. Ruangrungsi, N.; Lange, G.L.; Organ, M.G Fitoterapia LXV, 1994, 179-180. Coumarins From the Leaves of Triphasia trifolia.
8. Lange, G.L.; Organ, M.G. Tetrahedron Lett. 1993, 34, 1425-1428. Asymmetric Induction in Cuprate and Photoadditions to 2-t-Butyl-2,6-dimethyl-1,3-dioxin-4-one. Absolute but Opposite Face Selectivity.(https://doi.org/10.1016/S0040-4039(00)60309-X)
7. Lange, G.L.; Organ, M.G.; Roche, M.R. J. Org. Chem. 1992, 57, 6000-6003. Bromination of 2,2,6-trialkyl-1,3-dioxan-4-ones. Application of the Deuterium Isotope Effect to the Synthesis of a Chiral Trialkyldioxinone.(https://doi.org/10.1021/jo00048a039)
6. Ruangrungsi, N.; Prathanturarug, S.; Lange, G.L.; Organ, M.G. Phytochemistry 1992, 31, 2397-2400. An N-methyl Aristolactam and an Oxygenated Cyclohexane Derivative From Piper ribesioides.(https://doi.org/10.1016/0031-9422(92)83285-7)
5. Somanabandhu, A-o; Ruangrungsi, N.; Lange, G.L.; Organ, M.G. Thai. J. Pharm. Sci. 1992, 16, 207-211. Constituents of the Stem Bark of Zanthoxylum limonella.(http://www.scienceasia.org/1992.18.n3/v18_181_185.pdf)
4. Lange, G.L.; Organ, M.G. Synlett 1991, 665-667. Conversion of 5-Oxoalkanals to d- Lactones by an Intramolecular Tishchenko Reaction.(http://doi.org/10.1055/s-0036-1589465)
3. Ruangrungsi, N.; Ariyaprayoon, J.; Lange, G.L.; Organ, M.G J. Nat. Prod. 1990, 53, 946-952. Three New Carbazole Alkaloids Isolated From Maurraya siamensis.(https://doi.org/10.1021/np50070a025)
2. Lange, G.L.; Organ, M.G.; Lee, M. Tetrahedron Lett. 1990, 31, 4689-4692. Reversal of Regioselectivity with Increasing Ring Size of Alkene Component in [2+2] Photoadditions.(https://doi.org/10.1016/S0040-4039(00)97707-4)
1. Organ, M.G.; Greenwood, J.S.; Bewley, J.D. Planta 1988, 174, 513-517. Phytin is Synthesized in the Cotyledons of Germinated Castor-Bean Seeds in Response to Exogenously Supplied Phosphate.(https://doi.org/10.1007/bf00634481)
Book Chapters:
4. “The Contemporary Suzuki-Miyaura Reaction” Cory Valente and Michael G. Organ. Boronic Acids 2nd Ed, 2010.
3. “Synthesis by Metal Substitution of Metals with Extension of the Carbon Framework." Michael G. Organ and Eric A. Kantchev. Science of Synthesis. 2009, 48, 29-95.
2. “Synthesis by Metal Substitution of Metals with Retention of the Carbon Framework." Michael G. Organ and Eric A. Kantchev. Science of Synthesis. 2009, 48, 9-28.
1. “Optimizing Solution Phase Synthesis Using Solid Phase Techniques. “ Michael G. Organ* and Debasis Mallik. Optimizing Solid-Phase Chemistry. Marcel-Dekker, New York. 2001. 315-381.
Technical Reports:
1. Dixon, C.G.; Organ, M.G.; Porco, J.A. Argonaut Technologies Technical Report 1999. Invited Feature Report Entitled: Parallel Synthesis of Amino-Substituted Biaryls on the Quest 210: Use of Bank-to-Bank Transfer.
Patents and Patents Pending:
14. Organ, M. G.; Mallik, D. Device for Mapping Constitutional Composition of a Flow Stream. US Patent Application # 63020194
13. Elhalfawy, O.; Brown, E.; Czarny, T.; Organ, M. G.; Day, J. Compounds that target the bacterial envelop stress response and reverse b-lactam resistance in MRSA. US Patent Application # 62800155
12. Organ, M. G., Zhang, W., Mallik, D. Fluid diverting module, US 62/652,360
11. Mallik, D.; Organ, M. G. Multidimensional Peak Purity Analysis. US Application Number: US 2018/0128795 A1
10. Mallik, D.; Organ, M. G.; Kwak, J. S.;. Non-disruptive Sampler for Fluid Processing Apparatus. US 2017/0248502 A1
9. Organ, M. G.; Mallik, D. Fluid Processing Apparatus. US Patent Publication No. 9,579,625
8. Zablocki, J.; Abelman, M.; Organ, M. G.; Bilokin, Y.; Diamond, I.; Arolfo, M. P.; Yao, L.; Fan, P.; Elzein, E.; Kalla, R.; Perry, T.; Kobayashi, T.; Lee, X.; Jiang, R. ALDH-2 Inhibitors in the Treatment of Addiction. US Patent Application No. 11/829,836. US Patent Publication No. 20090209533 US20080032995, WO2008014497 A2, Filed: Jul 27, 2007, Date Granted: Jan 31, 2008
7. Abelman, M.; Organ, G. G.; Zablocki, J.; Keung, W. M.; Tao, G. Quinazolinone derivatives as ALDH-2 inhibitors, Filed April 3, 2008, Granted May 31, 2011. US Patent Number: 7,951,813
6. Zablocki, J.; Elzein, E.; Organ, M. G.; Bilokin, Y.; Mayer, S.; Disanti, A.; Miller, S. A.; Kernast, P. A. Process for the preparation of thionucleoside analog via condensation of 5'-deoxychloro nucleosides with thiols as A1 adenosine receptor agonists. Filed August 29, 2005, Patent Granted Nov 28, 2007. US Patent number: 07300923.
5. Organ, M. G.; O’Brien, C. J.; Kantchev, E. A. B. Canadian Provisional Application Entitled: “Easily Prepared Air Stable Catalysts and Pre-catalysts for Transition Metal Catalyzed Organic Transformations. US60/710,869. Filed June 30, 2006.
4. Organ, M. G.; O’Brien, C. J.; Kantchev, E. A. B. US Provisional Application Entitled : “Easily Prepared Air Stable Catalysts and Pre-catalysts for Transition Metal Catalyzed Organic Transformations. US60/710,869. Filed August 25, 2005. Patent Granted July 31, 2007. US Patent Number: 7250510 B2.
3. Organ, M. G.; Connop, B. P.; MacDonald, D.; Nathwani, P. US Provisional Application Entitled Arylthioetherpyrimidine and Aryloxyetherpyrimidine Derivatives and Their Therapeutic Uses. PCT Int. Appl. (2004), 98 pp. WO 2004054988 A1 20040701 CAN 141:89099 AN 2004:534184.
2. Comer, E.; Organ, M. G. European Patent: Method and Apparatus for Performing Micro-Scale Chemical Reactions. Granted December 28, 2012. EP Patent Application No. 05778890.3-1270.
1. Organ, Michael G.; Dixon, Craig E.; Kaldor, Stephen W.; Siegel, Miles G. Solution-phase synthesis of olefins and olefin-derived products. PCT Int. Appl. (1999), 35 pp.